| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T428 |
0-173 |
Sentence |
denotes |
The distribution of a drug is regulated by many parameters such as lipid-solubility, concentration in plasma and binding ability to plasma proteins, transport proteins, etc. |
| T429 |
174-353 |
Sentence |
denotes |
The volume of distribution at steady-state (VDss) suggests that EGCG, TF2a, TF2b, TF3, and remdesivir had a lower theoretical dose required for uniform distribution in the plasma. |
| T430 |
354-586 |
Sentence |
denotes |
Further, the degree of diffusion across the plasma membrane increases in the following order remdesivir < EGCG < TF2a < TF2b < TF3 (Table S4 in the Supplementary Information) as measured by the fraction that is in the unbound state. |
| T431 |
587-817 |
Sentence |
denotes |
The predictions through the distribution of the drugs via the central nervous system and blood-brain barrier suggest that these five compounds are poorly distributed to the brain and unable to penetrate the central nervous system. |
| T432 |
818-954 |
Sentence |
denotes |
However, the medium level of the lipophilicity of the drugs suggests that they would have no negative impact on nervous system exposure. |
