LitCovid-sentences  

PMC:7435837 / 46841-48059 JSONTXT 7 Projects

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Id Subject Object Predicate Lexical cue
T364 41-165 Sentence denotes The virus spike proteins interact with ACE-2 receptors and this provides the route of entry of the virus into the host cell.
T365 166-168 Sentence denotes 1.
T366 169-256 Sentence denotes Drugs such as arbidol interfere with the binding of spike proteins with ACE-2 receptor.
T367 257-259 Sentence denotes 2.
T368 260-371 Sentence denotes Priming of the spike protein to enhance its affinity for ACE-2 receptors is hampered by, for example, camostat.
T369 372-374 Sentence denotes 3.
T370 375-455 Sentence denotes Virus-host membrane fusion could be prevented by drugs such as chloroquine. (B).
T371 456-526 Sentence denotes The successful fusion of the virus and host membrane is achieved. (C).
T372 527-602 Sentence denotes The coronavirus sheds its RNA which can then be translated to polypeptides.
T373 603-704 Sentence denotes The polypeptides as cleaved by the enzyme, 3-chymotrypsin protease to render non-structural proteins.
T374 705-775 Sentence denotes This proteolysis step, 4, can be inhibited by, for example, lopinavir.
T375 776-901 Sentence denotes Drug target 5, prohibits the further conversion of non-structural to structural proteins by RNA-dependent polymerase enzymes.
T376 902-965 Sentence denotes Remdesivir is a prime example of an inhibitor of target 5. (D).
T377 966-1045 Sentence denotes Virus assembly has been completed and the virus is expelled from the host cell.
T378 1046-1192 Sentence denotes The virus can then be intercepted by dendritic cells or other immune factors such as interferons (not discussed) or restart the replication cycle.
T379 1193-1218 Sentence denotes Figure adapted from [40].