| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T110 |
0-157 |
Sentence |
denotes |
Since these molecules are polymers, numerous sites for binding interactions exist and pathogens might even be capable of incorporating host cell glycans [9]. |
| T111 |
158-366 |
Sentence |
denotes |
Coronaviruses have been known to interact with heparin sulfate proteoglycans, one of the most commonly occurring glycoproteins in eukaryotic organisms, and facilitate virion adsorption to cell membranes [63]. |
| T112 |
367-589 |
Sentence |
denotes |
The spike protein of SARS-CoV-2 is shown to interact with heparin which is derived from the GAG, heparan sulfate and this indicated a potential target for heparan and heparin-derived drugs against SARS-CoV-2 [64,65,66,67]. |
| T113 |
590-685 |
Sentence |
denotes |
Heparan sulfate is a promising target since heparin glycans are widely expressed in lung cells. |
| T114 |
686-815 |
Sentence |
denotes |
Heparan sulfate is an important co-receptor for ACE-2 since ACE-2 receptor expression is too low to directly result in infection. |
| T115 |
816-990 |
Sentence |
denotes |
SARS-CoV [68,69] and CoV-NL63 [70] coronaviruses initially bind to heparin sulfate which concentrates the virion concentration close to the ACE-2 receptor for cellular entry. |
