| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T295 |
0-118 |
Sentence |
denotes |
Figure 8 Aging reprograms human immune cell landscape, and increases the susceptibility and vulnerability of COVID-19. |
| T296 |
119-253 |
Sentence |
denotes |
Schematic illustrating the key innate and adaptive immune functional alterations identified in PBMCs influenced by aging and COVID-19. |
| T297 |
254-356 |
Sentence |
denotes |
Young healthy individuals maintain homeostasis in immune system which could timely eliminate pathogen. |
| T298 |
357-459 |
Sentence |
denotes |
Aging leads to the increase of monocytes (MCs) and the decrease of T cells (TCs) in the immune system. |
| T299 |
460-711 |
Sentence |
denotes |
Aging promotes the polarization of TCs from naive and memory to effector, exhausted and regulatory subtypes and increases the numbers of late natural killer (NK) cells, age-associated B cells, inflammatory MCs, and dysfunctional dendritic cells (DCs). |
| T300 |
712-855 |
Sentence |
denotes |
Moreover, aging induces increased expression of genes related to SARS-CoV-2 susceptibility, suggesting increased susceptibility in the elderly. |
| T301 |
856-961 |
Sentence |
denotes |
Importantly, aging induces DCs to lose the antigen-presenting ability, and turn to an inflammatory state. |
| T302 |
962-1149 |
Sentence |
denotes |
Together, a dysregulated immune system and increased expression of genes associated with SARS-CoV-2 susceptibility may at least partially account for COVID-19 vulnerability in the elderly |
