| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T166 |
0-190 |
Sentence |
denotes |
In TCs, a series of subset-specific TF changes were observed, such as GLI2 in naive cells, which has been associated with decreased TC function and impaired immune defenses (Fig. 4F and 4G). |
| T167 |
191-275 |
Sentence |
denotes |
Consistently, increased chromatin accessibility was detected in GLI2 loci (Fig. 4N). |
| T168 |
276-466 |
Sentence |
denotes |
Analysis of differentially accessible regions (DARs) demonstrated that the IFNG, DUSP5, and GZMB loci were highly accessible, which indicated activated CD8+ TC states (Figs. 4O, 4P and S8J). |
| T169 |
467-702 |
Sentence |
denotes |
In our analysis of NK status, we identified the key TF changes in NK subsets during aging (Fig. 4H), and found that the chromatin accessibility of the inhibitory receptor gene increased, while that of the activating receptor decreased. |
| T170 |
703-770 |
Sentence |
denotes |
These changes may weaken the ability to clear virus-infected cells. |
| T171 |
771-966 |
Sentence |
denotes |
For example, the PDCD1 exhibited higher chromatin accessibility in the gene region of the elderly group, which might be part of the reason why older individuals were prone to infection (Fig. 4Q). |
| T172 |
967-1110 |
Sentence |
denotes |
In our analysis of BCs, we identified aging-related TF changes, such as TBX21, IRF4, which are consistent with our scRNA-seq results (Fig. 4I). |
| T173 |
1111-1306 |
Sentence |
denotes |
Aging-associated TFs and DARs in MCs demonstrated enrichment in inflammatory-related TFs and gene loci in the AA group, such as NF-κB family (REL, RELA), IL1B, TNF and CXCL8 (Figs. 4I and S8K–M). |
| T174 |
1307-1459 |
Sentence |
denotes |
In summary, aging-related chromosomal accessibility changes are associated with an increase in the inflammatory pathway and an impaired immune response. |
