| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T131 |
0-131 |
Sentence |
denotes |
Within DC clusters, we found distinct aging manifestations in the cDC2 subsets by comparing DC clusters in the t-SNE map (Fig. 3J). |
| T132 |
132-300 |
Sentence |
denotes |
Cells from the YA group grouped together in clusters 0 and 1 (named cDC2-A), whereas cells in AA group grouped distinctively in clusters 3, 4, 10 and 11 (named cDC2-B). |
| T133 |
301-605 |
Sentence |
denotes |
The expression signature of cDC2-A cells included antigen presentation-related genes such as AHR, CLEC4E, and CLEC12A, whereas the expression signature of cDC2-B cells included inflammatory and aging-associated genes such as IFN-stimulated genes, IL1B, CDKN2D, DDIT4, CXCL8, and DUSP2 (Fig. S7J and S7K). |
| T134 |
606-942 |
Sentence |
denotes |
Moreover, the comparative functional analysis of DEGs between the two clusters indicated that cDC2-A had intact immune regulation and antigen presentation function, while aging-related cDC2-B with high HLA-DQA2 expression exhibited increased inflammatory signaling pathways, such as the response to hypoxia and IL-1 signaling (Fig. 3K). |
| T135 |
943-1033 |
Sentence |
denotes |
We further confirmed that CLEC12A+ cDC2s were decreased in aging by FACS (Fig. 3L and 3M). |
| T136 |
1034-1199 |
Sentence |
denotes |
Taken together, these findings indicate that aging curtails DC antigen presentation ability and upregulates inflammatory and aging-associated gene expression in DCs. |
