LitCovid-sentences  

PMC:7417788 / 1465-6033 JSONTXT 12 Projects

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Id Subject Object Predicate Lexical cue
T12 0-12 Sentence denotes INTRODUCTION
T13 13-166 Sentence denotes The world population is undergoing a rapid expansion of older adults, and thus, exploring how to stay healthy with age has become an urgent global focus.
T14 167-468 Sentence denotes Aging leads to numerous physiological changes, including the deterioration of the immune system, rendering the elderly more susceptible to infections, such as the COVID-19 pandemic, and poor responses to vaccines (Ciabattini et al., 2018; Alpert et al., 2019; Onder et al., 2020; Verity et al., 2020).
T15 469-601 Sentence denotes Changes observed during aging are often reflected as alterations in the composition and functional declines of diverse immune cells.
T16 602-942 Sentence denotes For T cells (TCs), the high frequency of naive cells in young humans progressively decreases along with the accumulation of highly differentiated memory cells (Hakim and Gress, 2007), whereas nonclassical monocytes (MCs) with high levels of plasma tumor necrosis factor (TNF)-α and interleukin (IL)-8 accumulate with age (Ong et al., 2018).
T17 943-1208 Sentence denotes In addition, senescence of the immune system in the elderly has been termed “inflammaging”, which refers to increased levels of tissue and circulating proinflammatory cytokines in the absence of an immunological threat (Panda et al., 2009; Franceschi et al., 2018).
T18 1209-1370 Sentence denotes Overall, aging is associated with changes in the structure of diverse immune compartments, where accumulating dysfunctional subsets contribute to immune failure.
T19 1371-1581 Sentence denotes Seminal studies have provided insights into the compositions and functional alterations occurring during aging, primarily based on previously described markers detected in pooled heterogeneous cell populations.
T20 1582-1813 Sentence denotes The recent development of unbiased high-throughput single-cell technologies with high accuracy and specificity has begun to change immunological studies, as researchers worldwide are ushering in the new field of systems immunology.
T21 1814-2069 Sentence denotes By using single-cell sequencing, recent studies have reported that cell-to-cell transcriptional variability increases with age in CD4+ TCs (Bahar et al., 2006; Martinez-Jimenez et al., 2017) and in leukocytes from old mouse lungs (Angelidis et al., 2019).
T22 2070-2177 Sentence denotes Aging also increases the variations in chromatin modifications of human immune cells (Cheung et al., 2018).
T23 2178-2422 Sentence denotes Very recently, many immunological phenotypes, such as intratissue accumulation of proinflammatory cells, have been reported in aging rodent and primate models (Messaoudi et al., 2006; Watson et al., 2017; Hammond et al., 2019; Ma et al., 2020).
T24 2423-2590 Sentence denotes However, a comprehensive aging cell atlas of human peripheral blood that systematically connects all the blood lineages and cell subtypes has not yet been constructed.
T25 2591-2872 Sentence denotes Here, we applied single-cell RNA sequencing (scRNA-seq), mass cytometry (CyTOF), and single-cell assay for transposase-accessible chromatin sequencing (scATAC-seq) to comprehensively characterize the properties of peripheral blood mononuclear cells (PBMCs) in young and old adults.
T26 2873-3143 Sentence denotes We also enrolled young and aged COVID-19 patients in the incipient stage and recovery stage to explore how age influenced the capacity for recovery and prognosis of COVID-19 infection and to better understand the influence of immune dysregulation in aging and infection.
T27 3144-3425 Sentence denotes Our data revealed that aging promotes the polarization of TCs from naive and memory to effector, exhausted and regulatory subtypes and increases the numbers of late natural killer cells (NKs), age-associated B cells (BCs), inflammatory MCs, and dysfunctional dendritic cells (DCs).
T28 3426-3658 Sentence denotes With single-cell paired T/B cell receptor sequencing (scTCR/BCR-seq), we uncovered decreased diversity and increased clonality of effector, cytotoxic and exhausted CD8+ TC subsets in TCs and age-associated B subsets in BCs with age.
T29 3659-3819 Sentence denotes Notably, aging increased the expression of inflammation-related genes, senescence-related genes, and coronavirus susceptibility genes in specific cell subtypes.
T30 3820-4010 Sentence denotes Most impressively, COVID-19 caused similar immune cell landscape changes to that of aging and further increased aging-induced immune cell polarization and upregulation of inflammatory genes.
T31 4011-4286 Sentence denotes Increased SARS-CoV-2 susceptibility gene expression and inflammatory MCs and decreased TCs aggravate inflammatory storms and lymphopenia (Mehta et al., 2020; Merad and Martin, 2020; Zhou et al., 2020) and likely underlie the high susceptibility and mortality of old patients.
T32 4287-4568 Sentence denotes Overall, this work expands our knowledge of aging via single-cell transcriptomic, proteomic and chromatin accessibility immune cell profiling and highlights critical nodes between the dysregulated immune system and infections that may serve to modulate the process of inflammaging.