LitCovid-sentences  

PMC:7417201 / 3826-9827 JSONTXT 13 Projects

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Id Subject Object Predicate Lexical cue
T27 0-7 Sentence denotes Methods
T28 9-23 Sentence denotes Study protocol
T29 24-115 Sentence denotes All patients included in the study were part of ongoing prospective dedicated database [9].
T30 116-303 Sentence denotes The study was approved by the Ethical Committee “Carlo Romano,” University of Naples Federico II, and all patients were informed and signed a written consent to participate to this study.
T31 305-325 Sentence denotes Clinical definitions
T32 326-557 Sentence denotes As part of the baseline examination, clinical teams collected information on traditional cardiovascular risk factors, including age, gender, chest pain, smoking history, family history of CAD, diabetes, hypertension, and known CAD.
T33 558-706 Sentence denotes Chest pain was classified according to the American College of Cardiology/American Heart Association 2002 guideline update on exercise testing [10].
T34 707-824 Sentence denotes Patients were considered as having diabetes if they were receiving treatment with oral hypoglycemic drugs or insulin.
T35 825-951 Sentence denotes A family history of premature CAD was defined as a diagnosis of CAD in a first-degree relative prior to or at 55 years of age.
T36 952-1050 Sentence denotes Hypertension was defined as a blood pressure > 140/90 mmHg or use of anti-hypertensive medication.
T37 1051-1168 Sentence denotes Hyperlipidemia was defined as total cholesterol level > 6.2 mmol/L or treatment with cholesterol lowering medication.
T38 1169-1229 Sentence denotes Smoking history was defined as prior or current tobacco use.
T39 1230-1622 Sentence denotes A patient was considered to have known CAD at the time of imaging based on a provided history of previously diagnosed atherosclerotic coronary disease, history of myocardial infarction (chest pain or equivalent symptom complex, positive cardiac biomarkers, or typical electrocardiographic changes), history of percutaneous coronary intervention, or history of coronary artery bypass grafting.
T40 1624-1652 Sentence denotes Myocardial perfusion imaging
T41 1653-1868 Sentence denotes Patients underwent stress-optional rest 99mTc sestamibi-gated stress SPECT-MPI by physical exercise or dipyridamole stress test, according to the recommendations of the European Association of Nuclear Medicine [11].
T42 1869-2142 Sentence denotes During the pandemic, pharmacological stress was preferred to exercise stress test and criteria to prioritize patients were implemented, according to the recommendations of the American Society of Nuclear Cardiology and Society of Nuclear Medicine and Molecular Imaging [4].
T43 2143-2306 Sentence denotes Decisions were made based on clinical judgment on expected benefit to guide management, on the urgency of the test, and in discussion with the referring clinician.
T44 2307-2739 Sentence denotes SPECT-MPI was performed as scheduled: (1) for evaluation of ischemia in moderate- to high-risk patients considered for urgent coronary revascularization, (2) in patients with intermediate pretest CAD likelihood or when suspicion of CAD was high but coronary angiography had greater risk, and (3) for evaluation of ischemia in moderate- to high-risk patients in whom surgical procedure was urgent and revascularization was an option.
T45 2740-2881 Sentence denotes On the other hand, the test was postponed by 2–4 months for evaluation of ischemia follow-up when there was no urgent revascularization plan.
T46 2882-3026 Sentence denotes At peak exercise, or 4 min after completion of dipyridamole infusion, a bolus of 155 MBq of 99mTc-sestamibi was intravenously injected [12, 13].
T47 3027-3267 Sentence denotes For stress imaging studies, recordings were obtained by cadmium-zinc telluride (CZT)-SPECT (D-SPECT, Spectrum Dynamics, Caesarea, Israel) system using 9 pixilated CZT crystal detector columns mounted vertically spanning a 90° geometry [14].
T48 3268-3364 Sentence denotes Each of the columns consists of 1024 (16 × 64) 5-mm thick CZT crystal elements (2.46 × 2.46 mm).
T49 3365-3558 Sentence denotes Square hole tungsten collimators are fitted to each of the detectors, which are shorter than conventional low-energy, high-resolution collimators, yielding significantly better geometric speed.
T50 3559-3662 Sentence denotes Data were acquired focusing on the heart by the detectors rotating in synchrony and saved in list mode.
T51 3663-3730 Sentence denotes Images were obtained with the patient in a semi-recumbent position.
T52 3731-3907 Sentence denotes A 10-s pre-scan acquisition was performed to identify the location of the heart and to set the angle limits of scanning for each detector (region of interest-centric scanning).
T53 3908-4054 Sentence denotes Using the myocardial count rate from the pre-scan acquisition, the time per projection was set to target the recording of 1000 myocardial kcounts.
T54 4055-4186 Sentence denotes For rest-optional images, a second intravenous bolus of 370 MBq of 99mTc-sestamibi was injected followed by rest imaging recording.
T55 4187-4264 Sentence denotes The duration of the scans was less than 10 min for stress and 4 min for rest.
T56 4265-4429 Sentence denotes Summed and gated projections were reconstructed with an iterative maximum likelihood expectation maximization algorithm using 7 and 4 iterations, respectively [15].
T57 4431-4453 Sentence denotes Imaging interpretation
T58 4454-4713 Sentence denotes An automated software program (e-soft, 2.5, QGS/QPS, Cedars-Sinai Medical Center, Los Angeles, CA) was used to calculate the scores incorporating both the extent and severity of perfusion defects, using standardized segmentation of 17 myocardial regions [16].
T59 4714-4900 Sentence denotes The summed stress score (SSS), representing the total abnormal myocardium (i.e., necrotic and ischemic tissue), was obtained by adding the scores of the 17 segments of the stress images.
T60 4901-4940 Sentence denotes A SSS > 3 was considered abnormal [17].
T61 4941-5062 Sentence denotes A similar procedure was applied to the resting images to calculate the summed rest score and the summed difference score.
T62 5063-5254 Sentence denotes Total perfusion defect reflecting a combination of both severity and extent of myocardial defect was also calculated and categorized according to the presence of ≥ 10% of abnormal myocardium.
T63 5256-5276 Sentence denotes Statistical analysis
T64 5277-5371 Sentence denotes Continuous data are expressed as mean ± standard deviation and categorical data as percentage.
T65 5372-5492 Sentence denotes Student’s t test and χ2 test were used to compare the differences in continuous and categorical variables, respectively.
T66 5493-5664 Sentence denotes Poisson regression was used to compare the number of SPECT-MPI test performed during the lockdown and those during the corresponding time interval of the previous 3 years.
T67 5665-5821 Sentence denotes Multivariable logistic regression analysis for predicting abnormal SPECT-MPI was performed for lockdown period and corresponding period of previous 3 years.
T68 5822-5877 Sentence denotes Two-tailed P values < 0.05 were considered significant.
T69 5878-6001 Sentence denotes Statistical analysis was performed with R software version 3.6.3 (R Foundation for Statistical Computing, Vienna, Austria).