| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T577 |
0-51 |
Sentence |
denotes |
Risk of infection due to kinase inhibitor treatment |
| T578 |
52-411 |
Sentence |
denotes |
For ABL inhibitors, including imatinib, dasatinib, nilotinib, basutinib, and ponatinib, there is a modest increased risk of overall infection, with a risk of invasive fungal infection, tuberculosis, and cytomegalovirus (especially with dasatinib, particularly after hematopoietic stem cell transplantation), and a risk of hepatitis B virus reactivation (155). |
| T579 |
412-681 |
Sentence |
denotes |
For the BTK/EGFR inhibitor, ibrutinib, there is a modest increased risk of overall infection, with a risk of pneumocystis jirovecil pneumonia, invasive fungal infection, and progressive multifocal leukoencephalopathy, and a risk of hepatitis B virus reactivation (155). |
| T580 |
682-1026 |
Sentence |
denotes |
For JAK inhibitors, including ruxolitinib, tofacitinib, baricitinib, there is a major increased risk of overall infection, with a risk of pneumocystis jirovecil pneumonia, herpes zoster, tuberculosis, cytomegalovirus, Epstein-Barr virus, and progressive multifocal leukoencephalopathy, as well as a risk of hepatitis B virus reactivation (155). |
| T581 |
1027-1320 |
Sentence |
denotes |
It should be noted that the overall risk of a COVID-19 patient being treated with JAK inhibitors and afflicted with tuberculosis as a side effect is likely exceptionally low, especially given that for a COVID-19 patient, treatments for many of the trials are carried out for a couple of weeks. |
| T582 |
1321-1597 |
Sentence |
denotes |
The risk of developing serious infections, such as tuberculosis, is higher for patients that are on medication causing chronic immunosuppression, such as would be the case for a patient with a chronic illness like rheumatologic disorders, or patients with latent tuberculosis. |
| T583 |
1598-1781 |
Sentence |
denotes |
However, with a short course of treatment in the case of a COVID-19 patient, it is unclear whether the period of immunosuppression would be long enough to result in a meaningful risk. |
| T584 |
1782-1873 |
Sentence |
denotes |
In addition, latent tuberculosis can be tested for rather quickly (1-2 days) with a T-spot. |
| T585 |
1874-1882 |
Sentence |
denotes |
TB test. |
| T586 |
1883-2049 |
Sentence |
denotes |
This would normally be carried out for patients treated with JAK inhibitors, although there may be more of a delay than is ideal for patients with high risk COVID-19. |
