PMC:7417114 / 56757-57222 10 Projects
Annnotations
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T472 | 0-19 | Sentence | denotes | Ceritinib (Zykadia) |
| T473 | 20-87 | Sentence | denotes | (Novartis) Cmax after approximately 4 to 6 h following oral dosin;g |
| T474 | 88-167 | Sentence | denotes | Vd= 4230 L (after 750 mg) Metabolized mainly by CYP3A 450 mg orally once daily; |
| T475 | 168-465 | Sentence | denotes | 97% binding Pulmonary toxicity, such as interstitial lung disease, is a rare side effect associated with ALK inhibitors; most can be managed efficiently by lowering doses or interrupting treatment; in a clinical trial, pneumonitis was reported in 4% of ceritinib-treated patients (238) (239) (240) |