PMC:7417114 / 52810-53319 JSONTXT 7 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T430 0-25 Sentence denotes Sunitinib malate (Sutent)
T431 26-72 Sentence denotes (Pfizer) Bioavailability not affected by food;
T432 73-119 Sentence denotes after oral dosing, Cmax observed 6-12 h (Tmax)
T433 120-130 Sentence denotes Vd= 2230 L
T434 131-152 Sentence denotes (substrate for ABCB1)
T435 153-280 Sentence denotes (184) Metabolized mainly by CYP3A4 50 mg orally once daily (4 weeks on, 2 weeks off); 37.5 mg orally (continuous daily dosing);
T436 281-444 Sentence denotes 95% binding for sunitinib, 90% binding for sunitinib’s primary metabolite (HSA) Dyspnea and cough have been reported in association with sunitinib treatment (229);
T437 445-509 Sentence denotes there are no reports of sunitinib treatment-induced pneumonitis.