| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T274 |
0-37 |
Sentence |
denotes |
PI3K/AKT/mTOR and ERK/MAPK inhibitors |
| T275 |
38-281 |
Sentence |
denotes |
Activation of the phosphatidylinositol 3’-kinase-Akt-mammalian target of rapamycin (PI3K/Akt/mTOR) pathway has been implicated in growth and replication of numerous viruses, including HCV, West Nile virus, and influenza A virus (65) (66) (67). |
| T276 |
282-702 |
Sentence |
denotes |
Pathway overrepresentation analysis and functional network analysis employed to identify cell signaling changes occurring during MERS-CoV infection (68) revealed members of the PI3K/AKT/mTOR signaling pathway, including AKT, target of rapamycin (mTOR), RPS6KB1, PDPK1, PIK3R1, and PIK3R2, and members of the Ras/Raf/MEK/ERK signaling pathway signaling pathway, including MAP2K1, MAPK3 and MAPK14, to be upregulated (68). |
| T277 |
703-894 |
Sentence |
denotes |
At a concentration of 10 μM, the mTOR inhibitor, rapamycin, caused significant (61%) inhibition of MERS-CoV infection (correlated with decreased viral titers) in MERS-CoV-infected cells (68). |
| T278 |
895-1017 |
Sentence |
denotes |
Treatment of cells prior to MERS-CoV infection with sorafenib, which targets RAF, strongly inhibited infection (93%) (68). |
| T279 |
1018-1163 |
Sentence |
denotes |
The inhibitory activity was diminished when sorafenib was added post-infection, suggesting a possible role for RAF early in the viral life cycle. |
| T280 |
1164-1370 |
Sentence |
denotes |
Genetic knockdown studies, focusing on mTOR and RAF and other signaling molecules shown to be overrepresented during MERS-CoV infection, are warranted to validate the role of these proteins in this process. |
| T281 |
1371-1520 |
Sentence |
denotes |
Activation of the MAPK/ERK1 pathway has been implicated in influenza A virus production and viral nuclear export of ribonucleoprotein complexes (69). |
| T282 |
1521-1676 |
Sentence |
denotes |
The pathway has also been associated with Ebola virus entry coupled with cellular (glycoprotein-induced) damage and elevated cytokine production (70) (71). |
