| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T465 |
0-110 |
Sentence |
denotes |
Based on the above described hypothesis, inhibition of ACE2 pathway might be beneficial for COVID-19 patients. |
| T466 |
111-371 |
Sentence |
denotes |
Indeed, the clinical picture as a whole is consistent with an ACE2 gain of function (possibly due to both circulating active forms of S1-sACE2 complexes and local forms of SARS-CoV-2-sACE2 complexes) rather than an ACE2 loss of function, as initially supposed. |
| T467 |
372-566 |
Sentence |
denotes |
Therefore, inhibition of ACE2/Ang (1–7)/MasR axis or other ACE2 pathways to restore ACE/ACE2 balance might be needed, at least in the first phases of the disease when hypoxia is not yet induced. |
| T468 |
567-708 |
Sentence |
denotes |
Different strategies could be pursued through ACE2 pathway inhibitors and/or MasR antagonists and/or renin inhibitors and/or metal chelators. |
