| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T167 |
0-82 |
Sentence |
denotes |
Mas receptor pathway inhibition and side effects of using Mas receptor inhibitors. |
| T168 |
83-246 |
Sentence |
denotes |
A779 also known as D-Ala7-Ang-(1–7) and D-Pro7-Ang-(1–7) are two distinct MasR antagonists able to prevent Ang-(1–7)-mediated downstream activation in human cells. |
| T169 |
247-620 |
Sentence |
denotes |
The existence of several MasR subtypes has been suggested based on the differential capacity of the two MasR blockers to fully inhibit some biological actions of Ang-(1–7) [and perhaps of Ang (1–5), see Figure 1] [39,70]; therefore, differently from ACE2 enzymatic inhibitors, MasR antagonists should be administered in combinations, in order to inhibit ACE2 hyperactivity. |
| T170 |
621-811 |
Sentence |
denotes |
In human aortic smooth muscle cells, they have been shown to restore NADPH oxidase/NF-kB/iNOS inflammatory pathway induced by Ang II when it is inhibited by Ang (1–7) co-administration [81]. |
| T171 |
812-1190 |
Sentence |
denotes |
In mice studies a MasR blocker (A779) administered alone was not associated with systolic blood pressure alterations, and the hypotensive effect produced by rACE2 co-infused with Ang II was unaffected by A779 co-administration, indicating that the hypotensive activity of rACE2 mainly depended on Ang II degradation rather than on increase of Ang (1–7) and MasR activation [82]. |
| T172 |
1191-1384 |
Sentence |
denotes |
In another report, spontaneously hypertensive rats (SHRs) that received A-779 alone for a total of two weeks did not significantly alter basal blood pressure and urinary protein excretion [83]. |
| T173 |
1385-1657 |
Sentence |
denotes |
Moreover, in SHRs treated with A-779 in combination with Ang II, renal injury and interstitial infiltration of macrophages and T cells were surprisingly reduced as compared with SHRs treated with Ang II alone, suggesting a safe use of A-779 drug in in vivo infusions [83]. |
| T174 |
1658-1814 |
Sentence |
denotes |
Another report showed that infusion of A-779 alone for 7 days did not produce a significant effect neither on blood pressure nor on heart rate in SHRs [84]. |
| T175 |
1815-2031 |
Sentence |
denotes |
In a rat model of cardiac arrhythmia, administration of A-779 alone did not cause any significant alteration in the number of arrhythmic events, confirming that A-779 can be safely delivered to rodents in vivo. [85]. |
| T176 |
2032-2382 |
Sentence |
denotes |
Although MasR antagonists has been shown to be safe in acute and chronic in vivo studies either with mice or rats, there are no data on administration in humans and the existence of different MasR subtypes in the vasculature require combinations of MasR antagonists to inhibit an excess of ACE2 activity as for example may occur in COVID-19 patients. |
