| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T68 |
0-122 |
Sentence |
denotes |
ACE and ACE2 are two zinc metalloproteases involved in the biogenesis of the components of renin-angiotensin system (RAS). |
| T69 |
123-323 |
Sentence |
denotes |
ACE2 processes angiotensin (Ang) I and II into Ang (1–9) and Ang (1–7), respectively, and it also has other known peptide targets, such as des-Arg(9)-bradykinin, which mediates B1 receptor activation. |
| T70 |
324-670 |
Sentence |
denotes |
Ang (1–7) and Ang (1–9) peptides, opposing the effects of ACE/Ang II/Ang II type 1 receptor (AT1R) pathway, are known to mediate vasodilatative (hypotension), antiproliferative and apoptotic effects through Mas and AT2 receptors, respectively, both involving downstream nitric oxide synthase (NOS) pathway activation [38,39,40,41,42,43,44,45,46]. |
| T71 |
671-826 |
Sentence |
denotes |
Physiology teaches us that there is a range of normality for every biological parameter, below (defect) and above (excess) of which there is a dysfunction. |
| T72 |
827-881 |
Sentence |
denotes |
This is likely to be true for ACE as well as for ACE2. |
| T73 |
882-1096 |
Sentence |
denotes |
It is well known that excessive Ang II/AT1R pathway activation induces vasoconstriction, aldosterone, inflammation, excessive cell proliferation, thrombosis, cardiac dysfunction and lung alterations (see Figure 1). |
| T74 |
1097-1389 |
Sentence |
denotes |
Moreover, most of the experiments show that increased ACE2 activity leads to beneficial effects; however, the experiments were usually performed using models in which its “antagonist“ (ACE) pathway was upregulated or ACE2 itself was downregulated, therefore balancing an unbalanced situation. |
| T75 |
1390-1449 |
Sentence |
denotes |
What does it happen in models in which the opposite occurs? |
