Id |
Subject |
Object |
Predicate |
Lexical cue |
T552 |
0-130 |
Sentence |
denotes |
At the moment, I am alone in proposing these new and non-conventional therapeutic approaches that may or may not work on COVID-19. |
T553 |
131-316 |
Sentence |
denotes |
In doing so, I have not only described a rationale/strategy to counter COVID-19, but also provided practical information to optimize the RAS inhibitors based on known experimental data. |
T554 |
317-506 |
Sentence |
denotes |
Before any in vivo drug administration (e.g., ACE2 inhibitor), it has to be checked the biological activity (e.g., ACE2) that is affected by the drug, considering the possible side effects. |
T555 |
507-685 |
Sentence |
denotes |
However, this is not always the case and, in some cases, patients are treated without a careful evaluation of the biological parameter that is modulated by the administered drug. |
T556 |
686-898 |
Sentence |
denotes |
In this regard, I have tried to address all aspects of the RAS inhibition in detail because my main concern is that the use of these approaches in a wrong way may lead to a failure or even to deleterious effects. |
T557 |
899-1142 |
Sentence |
denotes |
That is why I have meticulously described all the steps before possible administration and provided the guideline suggestions and specific recommendations in order to increase the probability of success and to minimize the deleterious effects. |
T558 |
1143-1243 |
Sentence |
denotes |
The readers are, however, expected and encouraged to debate and make their own optimized guidelines. |