LitCovid-sentences  

PMC:7408073 / 103321-104648 JSONTXT 9 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T502 0-4 Sentence denotes 8.2.
T503 5-34 Sentence denotes Inhibition of Renin Activity:
T504 35-44 Sentence denotes Aliskiren
T505 45-152 Sentence denotes An alternative approach is to inhibit the RAS pathway at its origin by inhibiting renin enzymatic activity.
T506 153-366 Sentence denotes Regarding renin inhibitors, aliskiren is the sole compound in this class of drugs that was approved by the US Food and Drug Administration in March 2007 and commercialized for the management of hypertension [186].
T507 367-503 Sentence denotes Aliskiren may be used alone or in combination with other drugs to face COVID-19, in particular the severe forms of SARS-CoV-2 infection.
T508 504-609 Sentence denotes Indeed, in patients with severe symptoms of COVID-19 hypoxia might have upregulated both arms of the RAS.
T509 610-772 Sentence denotes Therefore, aliskiren might be a useful “tool” to reduce production of Ang I, the necessary fuel for both ACE and ACE2 hyperactivity and their detrimental effects.
T510 773-989 Sentence denotes Aliskiren treatment in rats has been shown to upregulate both AT1R and MasR expression probably as consequence of a compensation mechanism when both Ang II and Ang (1–7) ligands are reduced by renin inhibition [187].
T511 990-1210 Sentence denotes Of particular interest in the context of SARS-CoV-2 infection, the treatment has been shown to reduce expression of both AT2R and ACE2, thus possibly performing a multiple action in inhibiting both arms of the RAS [187].
T512 1211-1327 Sentence denotes Similarly, cation chelating agents such as CaNa2EDTA or nicotianamine might also work, although at different levels.