LitCovid-sentences  

PMC:7405836 / 98759-105856 JSONTXT 10 Projects

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Id Subject Object Predicate Lexical cue
T684 0-22 Sentence denotes Therapeutics and Drugs
T685 23-234 Sentence denotes There is no currently licensed specific antiviral treatment for MERS- and SARS-CoV infections, and the main focus in clinical settings remains on lessening clinical signs and providing supportive care (183–186).
T686 235-513 Sentence denotes Effective drugs to manage COVID-19 patients include remdesivir, lopinavir/ritonavir alone or in a blend with interferon beta, convalescent plasma, and monoclonal antibodies (MAbs); however, efficacy and safety issues of these drugs require additional clinical trials (187, 281).
T687 514-671 Sentence denotes A controlled trial of ritonavir-boosted lopinavir and interferon alpha 2b treatment was performed on COVID-19 hospitalized patients (ChiCTR2000029308) (188).
T688 672-885 Sentence denotes In addition, the use of hydroxychloroquine and tocilizumab for their potential role in modulating inflammatory responses in the lungs and antiviral effect has been proposed and discussed in many research articles.
T689 886-968 Sentence denotes Still, no fool-proof clinical trials have been published (194, 196, 197, 261–272).
T690 969-1133 Sentence denotes Recently, a clinical trial conducted on adult patients suffering from severe COVID-19 revealed no benefit of lopinavir-ritonavir treatment over standard care (273).
T691 1134-1365 Sentence denotes The efforts to control SARS-CoV-2 infection utilize defined strategies as followed against MERS and SARS, along with adopting and strengthening a few precautionary measures owing to the unknown nature of this novel virus (36, 189).
T692 1366-1582 Sentence denotes Presently, the main course of treatment for severely affected SARS-CoV-2 patients admitted to hospitals includes mechanical ventilation, intensive care unit (ICU) admittance, and symptomatic and supportive therapies.
T693 1583-1864 Sentence denotes Additionally, RNA synthesis inhibitors (lamivudine and tenofovir disoproxil fumarate), remdesivir, neuraminidase inhibitors, peptide (EK1), anti-inflammatory drugs, abidol, and Chinese traditional medicine (Lianhuaqingwen and ShuFengJieDu capsules) could aid in COVID-19 treatment.
T694 1865-1961 Sentence denotes However, further clinical trials are being carried out concerning their safety and efficacy (7).
T695 1962-2292 Sentence denotes It might require months to a year(s) to design and develop effective drugs, therapeutics, and vaccines against COVID-19, with adequate evaluation and approval from regulatory bodies and moving to the bulk production of many millions of doses at commercial levels to meet the timely demand of mass populations across the globe (9).
T696 2293-2481 Sentence denotes Continuous efforts are also warranted to identify and assess viable drugs and immunotherapeutic regimens that revealed proven potency in combating other viral agents similar to SARS-CoV-2.
T697 2482-2575 Sentence denotes COVID-19 patients showing severe signs are treated symptomatically along with oxygen therapy.
T698 2576-2725 Sentence denotes In such cases where the patients progress toward respiratory failure and become refractory to oxygen therapy, mechanical ventilation is necessitated.
T699 2726-2823 Sentence denotes The COVID-19-induced septic shock can be managed by providing adequate hemodynamic support (299).
T700 2824-2937 Sentence denotes Several classes of drugs are currently being evaluated for their potential therapeutic action against SARS-CoV-2.
T701 2938-3239 Sentence denotes Therapeutic agents that have anti-SARS-CoV-2 activity can be broadly classified into three categories: drugs that block virus entry into the host cell, drugs that block viral replication as well as its survival within the host cell, and drugs that attenuate the exaggerated host immune response (300).
T702 3240-3324 Sentence denotes An inflammatory cytokine storm is commonly seen in critically ill COVID-19 patients.
T703 3325-3400 Sentence denotes Hence, they may benefit from the use of timely anti-inflammation treatment.
T704 3401-3619 Sentence denotes Anti-inflammatory therapy using drugs like glucocorticoids, cytokine inhibitors, JAK inhibitors, and chloroquine/hydroxychloroquine should be done only after analyzing the risk/benefit ratio in COVID-19 patients (301).
T705 3620-3757 Sentence denotes There have not been any studies concerning the application of nonsteroidal anti-inflammatory drugs (NSAID) to COVID-19-infected patients.
T706 3758-3902 Sentence denotes However, reasonable pieces of evidence are available that link NSAID uses with the occurrence of respiratory and cardiovascular adverse effects.
T707 3903-4042 Sentence denotes Hence, as a cautionary approach, it is better to recommend the use of NSAIDs as the first-line option for managing COVID-19 symptoms (302).
T708 4043-4173 Sentence denotes The use of corticosteroids in COVID-19 patients is still a matter of controversy and requires further systematic clinical studies.
T709 4174-4337 Sentence denotes The guidelines that were put forward to manage critically ill adults suggest the use of systemic corticosteroids in mechanically ventilated adults with ARDS (303).
T710 4338-4499 Sentence denotes The generalized use of corticosteroids is not indicated in COVID-19, since there are some concerns associated with the use of corticosteroids in viral pneumonia.
T711 4500-4678 Sentence denotes Stem cell therapy using mesenchymal stem cells (MSCs) is another hopeful strategy that can be used in clinical cases of COVID-19 owing to its potential immunomodulatory capacity.
T712 4679-4828 Sentence denotes It may have a beneficial role in attenuating the cytokine storm that is observed in severe cases of SARS-CoV-2 infection, thereby reducing mortality.
T713 4829-5026 Sentence denotes Among the different types of MSCs, expanded umbilical cord MSCs can be considered a potential therapeutic agent that requires further validation for managing critically ill COVID-19 patients (304).
T714 5027-5167 Sentence denotes Repurposed broad-spectrum antiviral drugs having proven uses against other viral pathogens can be employed for SARS-CoV-2-infected patients.
T715 5168-5315 Sentence denotes These possess benefits of easy accessibility and recognized pharmacokinetic and pharmacodynamic activities, stability, doses, and side effects (9).
T716 5316-5463 Sentence denotes Repurposed drugs have been studied for treating CoV infections, like lopinavir/ritonavir, and interferon-1β revealed in vitro anti-MERS-CoV action.
T717 5464-5689 Sentence denotes The in vivo experiment carried out in the nonhuman primate model of common marmosets treated with lopinavir/ritonavir and interferon beta showed superior protective results in treated animals than in the untreated ones (190).
T718 5690-5784 Sentence denotes A combination of these drugs is being evaluated to treat MERS in humans (MIRACLE trial) (191).
T719 5785-5968 Sentence denotes These two protease inhibitors (lopinavir and ritonavir), in combination with ribavirin, gave encouraging clinical outcomes in SARS patients, suggesting their therapeutic values (165).
T720 5969-6256 Sentence denotes However, in the current scenario, due to the lack of specific therapeutic agents against SARS-CoV-2, hospitalized patients confirmed for the disease are given supportive care, like oxygen and fluid therapy, along with antibiotic therapy for managing secondary bacterial infections (192).
T721 6257-6506 Sentence denotes Patients with novel coronavirus or COVID-19 pneumonia who are mechanically ventilated often require sedatives, analgesics, and even muscle relaxation drugs to prevent ventilator-related lung injury associated with human-machine incoordination (122).
T722 6507-6779 Sentence denotes The result obtained from a clinical study of four patients infected with COVID-19 claimed that combination therapy using lopinavir/ritonavir, arbidol, and Shufeng Jiedu capsules (traditional Chinese medicine) was found to be effective in managing COVID-19 pneumonia (193).
T723 6780-6929 Sentence denotes It is difficult to evaluate the therapeutic potential of a drug or a combination of drugs for managing a disease based on such a limited sample size.
T724 6930-7097 Sentence denotes Before choosing the ideal therapeutic agent for the management of COVID-19, randomized clinical control studies should be performed with a sufficient study population.