PMC:7405836 / 97231-98757 JSONTXT 8 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T672 0-184 Sentence denotes The heterologous immune effects induced by Bacillus Calmette Guérin (BCG) vaccination is a promising strategy for controlling the COVID-19 pandemic and requires further investigations.
T673 185-256 Sentence denotes BCG is a widely used vaccine against tuberculosis in high-risk regions.
T674 257-324 Sentence denotes It is derived from a live attenuated strain of Mycobacterium bovis.
T675 325-460 Sentence denotes At present, three new clinical trials have been registered to evaluate the protective role of BCG vaccination against SARS-CoV-2 (363).
T676 461-585 Sentence denotes Recently, a cohort study was conducted to evaluate the impact of childhood BCG vaccination in COVID-19 PCR positivity rates.
T677 586-743 Sentence denotes However, childhood BCG vaccination was found to be associated with a rate of COVID-19-positive test results similar to that of the nonvaccinated group (364).
T678 744-881 Sentence denotes Further studies are required to analyze whether BCG vaccination in childhood can induce protective effects against COVID-19 in adulthood.
T679 882-1013 Sentence denotes Population genetic studies conducted on 103 genomes identified that the SARS-CoV-2 virus has evolved into two major types, L and S.
T680 1014-1123 Sentence denotes Among the two types, L type is expected to be the most prevalent (∼70%), followed by the S type (∼30%) (366).
T681 1124-1285 Sentence denotes This finding has a significant impact on our race to develop an ideal vaccine, since the vaccine candidate has to target both strains to be considered effective.
T682 1286-1402 Sentence denotes At present, the genetic differences between the L and S types are very small and may not affect the immune response.
T683 1403-1526 Sentence denotes However, we can expect further genetic variations in the coming days that could lead to the emergence of new strains (367).