PMC:7405836 / 90345-91958 JSONTXT 8 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T628 0-118 Sentence denotes Multiepitope subunit vaccines can be considered a promising preventive strategy against the ongoing COVID-19 pandemic.
T629 119-218 Sentence denotes In silico and advanced immunoinformatic tools can be used to develop multiepitope subunit vaccines.
T630 219-395 Sentence denotes The vaccines that are engineered by this technique can be further evaluated using docking studies and, if found effective, then can be further evaluated in animal models (365).
T631 396-535 Sentence denotes Identifying epitopes that have the potential to become a vaccine candidate is critical to developing an effective vaccine against COVID-19.
T632 536-699 Sentence denotes The immunoinformatics approach has been used for recognizing essential epitopes of cytotoxic T lymphocytes and B cells from the surface glycoprotein of SARS-CoV-2.
T633 700-787 Sentence denotes Recently, a few epitopes have been recognized from the SARS-CoV-2 surface glycoprotein.
T634 788-959 Sentence denotes The selected epitopes explored targeting molecular dynamic simulations, evaluating their interaction with corresponding major histocompatibility complex class I molecules.
T635 960-1007 Sentence denotes They potentially induce immune responses (176).
T636 1008-1093 Sentence denotes The recombinant vaccine can be designed by using rabies virus (RV) as a viral vector.
T637 1094-1210 Sentence denotes RV can be made to express MERS-CoV S1 protein on its surface so that an immune response is induced against MERS-CoV.
T638 1211-1415 Sentence denotes The RV vector-based vaccines against MERS-CoV can induce faster antibody response as well as higher degrees of cellular immunity than the Gram-positive enhancer matrix (GEM) particle vector-based vaccine.
T639 1416-1498 Sentence denotes However, the latter can induce a very high antibody response at lower doses (167).
T640 1499-1613 Sentence denotes Hence, the degree of humoral and cellular immune responses produced by such vaccines depends upon the vector used.