LitCovid-sentences  

PMC:7405836 / 88296-90344 JSONTXT 7 Projects

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Id Subject Object Predicate Lexical cue
T615 0-220 Sentence denotes However, our previous attempts to develop a universal vaccine that is effective for both SARS-CoV and MERS-CoV based on T-cell epitope similarity pointed out the possibility of cross-reactivity among coronaviruses (172).
T616 221-317 Sentence denotes That can be made possible by selected potential vaccine targets that are common to both viruses.
T617 318-392 Sentence denotes SARS-CoV-2 has been reported to be closely related to SARS-CoV (173, 174).
T618 393-554 Sentence denotes Hence, knowledge and understanding of S protein-based vaccine development in SARS-CoV will help to identify potential S protein vaccine candidates in SARS-CoV-2.
T619 555-752 Sentence denotes Therefore, vaccine strategies based on the whole S protein, S protein subunits, or specific potential epitopes of S protein appear to be the most promising vaccine candidates against coronaviruses.
T620 753-850 Sentence denotes The RBD of the S1 subunit of S protein has a superior capacity to induce neutralizing antibodies.
T621 851-1031 Sentence denotes This property of the RBD can be utilized for designing potential SARS-CoV vaccines either by using RBD-containing recombinant proteins or recombinant vectors that encode RBD (175).
T622 1032-1232 Sentence denotes Hence, the superior genetic similarity existing between SARS-CoV-2 and SARS-CoV can be utilized to repurpose vaccines that have proven in vitro efficacy against SARS-CoV to be utilized for SARS-CoV-2.
T623 1233-1368 Sentence denotes The possibility of cross-protection in COVID-19 was evaluated by comparing the S protein sequences of SARS-CoV-2 with that of SARS-CoV.
T624 1369-1534 Sentence denotes The comparative analysis confirmed that the variable residues were found concentrated on the S1 subunit of S protein, an important vaccine target of the virus (150).
T625 1535-1657 Sentence denotes Hence, the possibility of SARS-CoV-specific neutralizing antibodies providing cross-protection to COVID-19 might be lower.
T626 1658-1840 Sentence denotes Further genetic analysis is required between SARS-CoV-2 and different strains of SARS-CoV and SARS-like (SL) CoVs to evaluate the possibility of repurposed vaccines against COVID-19.
T627 1841-2048 Sentence denotes This strategy will be helpful in the scenario of an outbreak, since much time can be saved, because preliminary evaluation, including in vitro studies, already would be completed for such vaccine candidates.