LitCovid-sentences  

PMC:7405836 / 45319-50904 JSONTXT 10 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T309 0-43 Sentence denotes CLINICAL PATHOLOGY OF SARS-CoV-2 (COVID-19)
T310 44-183 Sentence denotes The disease caused by SARS-CoV-2 is also named severe specific contagious pneumonia (SSCP), Wuhan pneumonia, and, recently, COVID-19 (110).
T311 184-358 Sentence denotes Compared to SARS-CoV, SARS-CoV-2 has less severe pathogenesis but has superior transmission capability, as evidenced by the rapidly increasing number of COVID-19 cases (111).
T312 359-450 Sentence denotes The incubation period of SARS-CoV-2 in familial clusters was found to be 3 to 6 days (112).
T313 451-552 Sentence denotes The mean incubation period of COVID-19 was found to be 6.4 days, ranging from 2.1 to 11.1 days (113).
T314 553-669 Sentence denotes Among an early affected group of 425 patients, 59 years was the median age, of which more males were affected (114).
T315 670-768 Sentence denotes Similar to SARS and MERS, the severity of this nCoV is high in age groups above 50 years (2, 115).
T316 769-898 Sentence denotes Symptoms of COVID-19 include fever, cough, myalgia or fatigue, and, less commonly, headache, hemoptysis, and diarrhea (116, 282).
T317 899-1100 Sentence denotes Compared to the SARS-CoV-2-infected patients in Wuhan during the initial stages of the outbreak, only mild symptoms were noticed in those patients that are infected by human-to-human transmission (14).
T318 1101-1229 Sentence denotes The initial trends suggested that the mortality associated with COVID-19 was less than that of previous outbreaks of SARS (101).
T319 1230-1424 Sentence denotes The updates obtained from countries like China, Japan, Thailand, and South Korea indicated that the COVID-19 patients had relatively mild manifestations compared to those with SARS and MERS (4).
T320 1425-1627 Sentence denotes Regardless of the coronavirus type, immune cells, like mast cells, that are present in the submucosa of the respiratory tract and nasal cavity are considered the primary barrier against this virus (92).
T321 1628-1797 Sentence denotes Advanced in-depth analysis of the genome has identified 380 amino acid substitutions between the amino acid sequences of SARS-CoV-2 and the SARS/SARS-like coronaviruses.
T322 1798-1933 Sentence denotes These differences in the amino acid sequences might have contributed to the difference in the pathogenic divergence of SARS-CoV-2 (16).
T323 1934-2118 Sentence denotes Further research is required to evaluate the possible differences in tropism, pathogenesis, and transmission of this novel agent associated with this change in the amino acid sequence.
T324 2119-2312 Sentence denotes With the current outbreak of COVID-19, there is an expectancy of a significant increase in the number of published studies about this emerging coronavirus, as occurred with SARS and MERS (117).
T325 2313-2412 Sentence denotes SARS-CoV-2 invades the lung parenchyma, resulting in severe interstitial inflammation of the lungs.
T326 2413-2501 Sentence denotes This is evident on computed tomography (CT) images as ground-glass opacity in the lungs.
T327 2502-2594 Sentence denotes This lesion initially involves a single lobe but later expands to multiple lung lobes (118).
T328 2595-2869 Sentence denotes The histological assessment of lung biopsy samples obtained from COVID-19-infected patients revealed diffuse alveolar damage, cellular fibromyxoid exudates, hyaline membrane formation, and desquamation of pneumocytes, indicative of acute respiratory distress syndrome (119).
T329 2870-2993 Sentence denotes It was also found that the SARS-CoV-2-infected patients often have lymphocytopenia with or without leukocyte abnormalities.
T330 2994-3134 Sentence denotes The degree of lymphocytopenia gives an idea about disease prognosis, as it is found to be positively correlated with disease severity (118).
T331 3135-3219 Sentence denotes Pregnant women are considered to have a higher risk of getting infected by COVID-19.
T332 3220-3381 Sentence denotes The coronaviruses can cause adverse outcomes for the fetus, such as intrauterine growth restriction, spontaneous abortion, preterm delivery, and perinatal death.
T333 3382-3563 Sentence denotes Nevertheless, the possibility of intrauterine maternal-fetal transmission (vertical transmission) of CoVs is low and was not seen during either the SARS- or MERS-CoV outbreak (120).
T334 3564-3653 Sentence denotes However, there has been concern regarding the impact of SARS-CoV-2/COVID-19 on pregnancy.
T335 3654-4036 Sentence denotes Researchers have mentioned the probability of in utero transmission of novel SARS-CoV-2 from COVID-19-infected mothers to their neonates in China based upon the rise in IgM and IgG antibody levels and cytokine values in the blood obtained from newborn infants immediately postbirth; however, RT-PCR failed to confirm the presence of SARS-CoV-2 genetic material in the infants (283).
T336 4037-4154 Sentence denotes Recent studies show that at least in some cases, preterm delivery and its consequences are associated with the virus.
T337 4155-4252 Sentence denotes Nonetheless, some cases have raised doubts for the likelihood of vertical transmission (240–243).
T338 4253-4365 Sentence denotes COVID-19 infection was associated with pneumonia, and some developed acute respiratory distress syndrome (ARDS).
T339 4366-4575 Sentence denotes The blood biochemistry indexes, such as albumin, lactate dehydrogenase, C-reactive protein, lymphocytes (percent), and neutrophils (percent) give an idea about the disease severity in COVID-19 infection (121).
T340 4576-4814 Sentence denotes During COVID-19, patients may present leukocytosis, leukopenia with lymphopenia (244), hypoalbuminemia, and an increase of lactate dehydrogenase, aspartate transaminase, alanine aminotransferase, bilirubin, and, especially, D-dimer (244).
T341 4815-5018 Sentence denotes Middle-aged and elderly patients with primary chronic diseases, especially high blood pressure and diabetes, were found to be more susceptible to respiratory failure and, therefore, had poorer prognoses.
T342 5019-5126 Sentence denotes Providing respiratory support at early stages improved the disease prognosis and facilitated recovery (18).
T343 5127-5317 Sentence denotes The ARDS in COVID-19 is due to the occurrence of cytokine storms that results in exaggerated immune response, immune regulatory network imbalance, and, finally, multiple-organ failure (122).
T344 5318-5585 Sentence denotes In addition to the exaggerated inflammatory response seen in patients with COVID-19 pneumonia, the bile duct epithelial cell-derived hepatocytes upregulate ACE2 expression in liver tissue by compensatory proliferation that might result in hepatic tissue injury (123).