PMC:7405836 / 41360-43065 JSONTXT 7 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T283 0-165 Sentence denotes Coronavirus is the most prominent example of a virus that has crossed the species barrier twice from wild animals to humans during SARS and MERS outbreaks (79, 102).
T284 166-294 Sentence denotes The possibility of crossing the species barrier for the third time has also been suspected in the case of SARS-CoV-2 (COVID-19).
T285 295-392 Sentence denotes Bats are recognized as a possible natural reservoir host of both SARS-CoV and MERS-CoV infection.
T286 393-521 Sentence denotes In contrast, the possible intermediary host is the palm civet for SARS-CoV and the dromedary camel for MERS-CoV infection (102).
T287 522-591 Sentence denotes Bats are considered the ancestral hosts for both SARS and MERS (103).
T288 592-694 Sentence denotes Bats are also considered the reservoir host of human coronaviruses like HCoV-229E and HCoV-NL63 (104).
T289 695-893 Sentence denotes In the case of COVID-19, there are two possibilities for primary transmission: it can be transmitted either through intermediate hosts, similar to that of SARS and MERS, or directly from bats (103).
T290 894-1157 Sentence denotes The emergence paradigm put forward in the SARS outbreak suggests that SARS-CoV originated from bats (reservoir host) and later jumped to civets (intermediate host) and incorporated changes within the receptor-binding domain (RBD) to improve binding to civet ACE2.
T291 1158-1316 Sentence denotes This civet-adapted virus, during their subsequent exposure to humans at live markets, promoted further adaptations that resulted in the epidemic strain (104).
T292 1317-1412 Sentence denotes Transmission can also occur directly from the reservoir host to humans without RBD adaptations.
T293 1413-1603 Sentence denotes The bat coronavirus that is currently in circulation maintains specific “poised” spike proteins that facilitate human infection without the requirement of any mutations or adaptations (105).
T294 1604-1705 Sentence denotes Altogether, different species of bats carry a massive number of coronaviruses around the world (106).