LitCovid-sentences  

PMC:7405836 / 22628-45317 JSONTXT 10 Projects

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Id Subject Object Predicate Lexical cue
T161 0-40 Sentence denotes CURRENT WORLDWIDE SCENARIO OF SARS-CoV-2
T162 41-230 Sentence denotes This novel virus, SARS-CoV-2, comes under the subgenus Sarbecovirus of the Orthocoronavirinae subfamily and is entirely different from the viruses responsible for MERS-CoV and SARS-CoV (3).
T163 231-290 Sentence denotes The newly emerged SARS-CoV-2 is a group 2B coronavirus (2).
T164 291-414 Sentence denotes The genome sequences of SARS-CoV-2 obtained from patients share 79.5% sequence similarity to the sequence of SARS-CoV (63).
T165 415-611 Sentence denotes As of 13 May 2020, a total of 4,170,424 confirmed cases of COVID-19 (with 287,399 deaths) have been reported in more than 210 affected countries worldwide (WHO Situation Report 114 [25]) (Fig. 3).
T166 612-672 Sentence denotes FIG 3 World map depicting the current scenario of COVID-19.
T167 673-780 Sentence denotes Shown are countries, territories, or regions with reported confirmed cases of SARS-CoV-2 as of 13 May 2020.
T168 781-888 Sentence denotes Different colors indicate different WHO designated geographical regions with the number of confirmed cases.
T169 889-979 Sentence denotes The WHO region-wise total number of confirmed cases is depicted in different color strips.
T170 980-1107 Sentence denotes The leading information on the confirmed cases and deaths from all six WHO designated regions are depicted in circled balloons.
T171 1108-1744 Sentence denotes The numbers of COVID-19 cases and fatalities on three major cruise ships are also depicted. (Based on data from the WHO at https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200513-covid-19-sitrep-114.pdf?sfvrsn=17ebbbe_4; updated numbers of cases, deaths, and patients recovered can be found at https://gisanddata.maps.arcgis.com/apps/opsdashboard/index.html#/bda7594740fd40299423467b48e9ecf6.) Initially, the epicenter of the SARS-CoV-2 pandemic was China, which reported a significant number of deaths associated with COVID-19, with 84,458 laboratory-confirmed cases and 4,644 deaths as of 13 May 2020 (Fig. 4).
T172 1745-1905 Sentence denotes As of 13 May 2020, SARS-CoV-2 confirmed cases have been reported in more than 210 countries apart from China (Fig. 3 and 4) (WHO Situation Report 114) (25, 64).
T173 1906-1969 Sentence denotes COVID-19 has been reported on all continents except Antarctica.
T174 1970-2198 Sentence denotes For many weeks, Italy was the focus of concerns regarding the large number of cases, with 221,216 cases and 30,911 deaths, but now, the United States is the country with the largest number of cases, 1,322,054, and 79,634 deaths.
T175 2199-2285 Sentence denotes Now, the United Kingdom has even more cases (226,4671) and deaths (32,692) than Italy.
T176 2286-2509 Sentence denotes A John Hopkins University web platform has provided daily updates on the basic epidemiology of the COVID-19 outbreak (https://gisanddata.maps.arcgis.com/apps/opsdashboard/index.html#/bda7594740fd40299423467b48e9ecf6) (238).
T177 2510-2562 Sentence denotes FIG 4 Bar graph and pie chart for cases and deaths.
T178 2563-2928 Sentence denotes Shown are laboratory-confirmed cases and deaths in China and the rest of the world due to SARS-CoV-2. (A) SARS-CoV-2 confirmed cases in the top five affected countries from each WHO designated region, where maximum casualties were reported to WHO until 13 May 2020. (B) Total numbers of deaths and cases in China only. (C) Total number of cases worldwide by region.
T179 2929-3120 Sentence denotes COVID-19 has also been confirmed on a cruise ship, named Diamond Princess, quarantined in Japanese waters (Port of Yokohama), as well as on other cruise ships around the world (239) (Fig. 3).
T180 3121-3256 Sentence denotes The significant events of the SARS-CoV-2/COVID-19 virus outbreak occurring since 8 December 2019 are presented as a timeline in Fig. 5.
T181 3257-3366 Sentence denotes FIG 5 Timeline depicting the significant events that occurred during the SARS-CoV-2/COVID-19 virus outbreak.
T182 3367-3489 Sentence denotes The timeline describes the significant events during the current SARS-CoV-2 outbreak, from 8 December 2019 to 13 May 2020.
T183 3490-3791 Sentence denotes At the beginning, China experienced the majority of the burden associated with COVID-19 in the form of disease morbidity and mortality (65), but over time the COVID-19 menace moved to Europe, particularly Italy and Spain, and now the United States has the highest number of confirmed cases and deaths.
T184 3792-4041 Sentence denotes The COVID-19 outbreak has also been associated with severe economic impacts globally due to the sudden interruption of global trade and supply chains that forced multinational companies to make decisions that led to significant economic losses (66).
T185 4042-4267 Sentence denotes The recent increase in the number of confirmed critically ill patients with COVID-19 has already surpassed the intensive care supplies, limiting intensive care services to only a small portion of critically ill patients (67).
T186 4268-4371 Sentence denotes This might also have contributed to the increased case fatality rate observed in the COVID-19 outbreak.
T187 4373-4432 Sentence denotes Viewpoint on SARS-CoV-2 Transmission, Spread, and Emergence
T188 4433-4511 Sentence denotes The novel coronavirus was identified within 1 month (28 days) of the outbreak.
T189 4512-4648 Sentence denotes This is impressively fast compared to the time taken to identify SARS-CoV reported in Foshan, Guangdong Province, China (125 days) (68).
T190 4649-4907 Sentence denotes Immediately after the confirmation of viral etiology, the Chinese virologists rapidly released the genomic sequence of SARS-CoV-2, which played a crucial role in controlling the spread of this newly emerged novel coronavirus to other parts of the world (69).
T191 4908-5013 Sentence denotes The possible origin of SARS-CoV-2 and the first mode of disease transmission are not yet identified (70).
T192 5014-5186 Sentence denotes Analysis of the initial cluster of infections suggests that the infected individuals had a common exposure point, a seafood market in Wuhan, Hubei Province, China (Fig. 6).
T193 5187-5306 Sentence denotes The restaurants of this market are well-known for providing different types of wild animals for human consumption (71).
T194 5307-5418 Sentence denotes The Huanan South China Seafood Market also sells live animals, such as poultry, bats, snakes, and marmots (72).
T195 5419-5503 Sentence denotes This might be the point where zoonotic (animal-to-human) transmission occurred (71).
T196 5504-5770 Sentence denotes Although SARS-CoV-2 is alleged to have originated from an animal host (zoonotic origin) with further human-to-human transmission (Fig. 6), the likelihood of foodborne transmission should be ruled out with further investigations, since it is a latent possibility (1).
T197 5771-6005 Sentence denotes Additionally, other potential and expected routes would be associated with transmission, as in other respiratory viruses, by direct contact, such as shaking contaminated hands, or by direct contact with contaminated surfaces (Fig. 6).
T198 6006-6200 Sentence denotes Still, whether blood transfusion and organ transplantation (276), as well as transplacental and perinatal routes, are possible routes for SARS-CoV-2 transmission needs to be determined (Fig. 6).
T199 6201-6253 Sentence denotes FIG 6 Potential transmission routes for SARS-CoV-2.
T200 6254-6413 Sentence denotes From experience with several outbreaks associated with known emerging viruses, higher pathogenicity of a virus is often associated with lower transmissibility.
T201 6414-6578 Sentence denotes Compared to emerging viruses like Ebola virus, avian H7N9, SARS-CoV, and MERS-CoV, SARS-CoV-2 has relatively lower pathogenicity and moderate transmissibility (15).
T202 6579-6693 Sentence denotes The risk of death among individuals infected with COVID-19 was calculated using the infection fatality risk (IFR).
T203 6694-6840 Sentence denotes The IFR was found to be in the range of 0.3% to 0.6%, which is comparable to that of a previous Asian influenza pandemic (1957 to 1958) (73, 277).
T204 6841-6982 Sentence denotes Notably, the reanalysis of the COVID-19 pandemic curve from the initial cluster of cases pointed to considerable human-to-human transmission.
T205 6983-7256 Sentence denotes It is opined that the exposure history of SARS-CoV-2 at the Wuhan seafood market originated from human-to-human transmission rather than animal-to-human transmission (74); however, in light of the zoonotic spillover in COVID-19, is too early to fully endorse this idea (1).
T206 7257-7466 Sentence denotes Following the initial infection, human-to-human transmission has been observed with a preliminary reproduction number (R0) estimate of 1.4 to 2.5 (70, 75), and recently it is estimated to be 2.24 to 3.58 (76).
T207 7467-7630 Sentence denotes In another study, the average reproductive number of COVID-19 was found to be 3.28, which is significantly higher than the initial WHO estimate of 1.4 to 2.5 (77).
T208 7631-7739 Sentence denotes It is too early to obtain the exact R0 value, since there is a possibility of bias due to insufficient data.
T209 7740-7863 Sentence denotes The higher R0 value is indicative of the more significant potential of SARS-CoV-2 transmission in a susceptible population.
T210 7864-8002 Sentence denotes This is not the first time where the culinary practices of China have been blamed for the origin of novel coronavirus infection in humans.
T211 8003-8141 Sentence denotes Previously, the animals present in the live-animal market were identified to be the intermediate hosts of the SARS outbreak in China (78).
T212 8142-8272 Sentence denotes Several wildlife species were found to harbor potentially evolving coronavirus strains that can overcome the species barrier (79).
T213 8273-8392 Sentence denotes One of the main principles of Chinese food culture is that live-slaughtered animals are considered more nutritious (5).
T214 8393-8522 Sentence denotes After 4 months of struggle that lasted from December 2019 to March 2020, the COVID-19 situation now seems under control in China.
T215 8523-8828 Sentence denotes The wet animal markets have reopened, and people have started buying bats, dogs, cats, birds, scorpions, badgers, rabbits, pangolins (scaly anteaters), minks, soup from palm civet, ostriches, hamsters, snapping turtles, ducks, fish, Siamese crocodiles, and other animal meats without any fear of COVID-19.
T216 8829-8910 Sentence denotes The Chinese government is encouraging people to feel they can return to normalcy.
T217 8911-9101 Sentence denotes However, this could be a risk, as it has been mentioned in advisories that people should avoid contact with live-dead animals as much as possible, as SARS-CoV-2 has shown zoonotic spillover.
T218 9102-9268 Sentence denotes Additionally, we cannot rule out the possibility of new mutations in the same virus being closely related to contact with both animals and humans at the market (284).
T219 9269-9364 Sentence denotes In January 2020, China imposed a temporary ban on the sale of live-dead animals in wet markets.
T220 9365-9497 Sentence denotes However, now hundreds of such wet markets have been reopened without optimizing standard food safety and sanitation practices (286).
T221 9498-9701 Sentence denotes With China being the most populated country in the world and due to its domestic and international food exportation policies, the whole world is now facing the menace of COVID-19, including China itself.
T222 9702-9782 Sentence denotes Wet markets of live-dead animals do not maintain strict food hygienic practices.
T223 9783-9956 Sentence denotes Fresh blood splashes are present everywhere, on the floor and tabletops, and such food customs could encourage many pathogens to adapt, mutate, and jump the species barrier.
T224 9957-10089 Sentence denotes As a result, the whole world is suffering from novel SARS-CoV-2, with more than 4,170,424 cases and 287,399 deaths across the globe.
T225 10090-10307 Sentence denotes There is an urgent need for a rational international campaign against the unhealthy food practices of China to encourage the sellers to increase hygienic food practices or close the crude live-dead animal wet markets.
T226 10308-10526 Sentence denotes There is a need to modify food policies at national and international levels to avoid further life threats and economic consequences from any emerging or reemerging pandemic due to close animal-human interaction (285).
T227 10527-10699 Sentence denotes Even though individuals of all ages and sexes are susceptible to COVID-19, older people with an underlying chronic disease are more likely to become severely infected (80).
T228 10700-10830 Sentence denotes Recently, individuals with asymptomatic infection were also found to act as a source of infection to susceptible individuals (81).
T229 10831-11017 Sentence denotes Both the asymptomatic and symptomatic patients secrete similar viral loads, which indicates that the transmission capacity of asymptomatic or minimally symptomatic patients is very high.
T230 11018-11097 Sentence denotes Thus, SARS-CoV-2 transmission can happen early in the course of infection (82).
T231 11098-11215 Sentence denotes Atypical clinical manifestations have also been reported in COVID-19 in which the only reporting symptom was fatigue.
T232 11216-11296 Sentence denotes Such patients may lack respiratory signs, such as fever, cough, and sputum (83).
T233 11297-11452 Sentence denotes Hence, the clinicians must be on the look-out for the possible occurrence of atypical clinical manifestations to avoid the possibility of missed diagnosis.
T234 11453-11653 Sentence denotes The early transmission ability of SARS-CoV-2 was found to be similar to or slightly higher than that of SARS-CoV, reflecting that it could be controlled despite moderate to high transmissibility (84).
T235 11654-11806 Sentence denotes Increasing reports of SARS-CoV-2 in sewage and wastewater warrants the need for further investigation due to the possibility of fecal-oral transmission.
T236 11807-11961 Sentence denotes SARS-CoV-2 present in environmental compartments such as soil and water will finally end up in the wastewater and sewage sludge of treatment plants (328).
T237 11962-12142 Sentence denotes Therefore, we have to reevaluate the current wastewater and sewage sludge treatment procedures and introduce advanced techniques that are specific and effective against SARS-CoV-2.
T238 12143-12304 Sentence denotes Since there is active shedding of SARS-CoV-2 in the stool, the prevalence of infections in a large population can be studied using wastewater-based epidemiology.
T239 12305-12494 Sentence denotes Recently, reverse transcription-quantitative PCR (RT-qPCR) was used to enumerate the copies of SARS-CoV-2 RNA concentrated from wastewater collected from a wastewater treatment plant (327).
T240 12495-12578 Sentence denotes The calculated viral RNA copy numbers determine the number of infected individuals.
T241 12579-12808 Sentence denotes The increasing reports of virus shedding via the fecal route warrants the introduction of negative fecal viral nucleic acid test results as one of the additional discharge criteria in laboratory-confirmed cases of COVID-19 (326).
T242 12809-12940 Sentence denotes The COVID-19 pandemic does not have any novel factors, other than the genetically unique pathogen and a further possible reservoir.
T243 12941-13056 Sentence denotes The cause and the likely future outcome are just repetitions of our previous interactions with fatal coronaviruses.
T244 13057-13157 Sentence denotes The only difference is the time of occurrence and the genetic distinctness of the pathogen involved.
T245 13158-13305 Sentence denotes Mutations on the RBD of CoVs facilitated their capability of infecting newer hosts, thereby expanding their reach to all corners of the world (85).
T246 13306-13374 Sentence denotes This is a potential threat to the health of both animals and humans.
T247 13375-13569 Sentence denotes Advanced studies using Bayesian phylogeographic reconstruction identified the most probable origin of SARS-CoV-2 as the bat SARS-like coronavirus, circulating in the Rhinolophus bat family (86).
T248 13570-13781 Sentence denotes Phylogenetic analysis of 10 whole-genome sequences of SARS-CoV-2 showed that they are related to two CoVs of bat origin, namely, bat-SL-CoVZC45 and bat-SL-CoVZXC21, which were reported during 2018 in China (17).
T249 13782-13937 Sentence denotes It was reported that SARS-CoV-2 had been confirmed to use ACE2 as an entry receptor while exhibiting an RBD similar to that of SARS-CoV (17, 87, 254, 255).
T250 13938-14030 Sentence denotes Several countries have provided recommendations to their people traveling to China (88, 89).
T251 14031-14191 Sentence denotes Compared to the previous coronavirus outbreaks caused by SARS-CoV and MERS-CoV, the efficiency of SARS-CoV-2 human-to-human transmission was thought to be less.
T252 14192-14336 Sentence denotes This assumption was based on the finding that health workers were affected less than they were in previous outbreaks of fatal coronaviruses (2).
T253 14337-14448 Sentence denotes Superspreading events are considered the main culprit for the extensive transmission of SARS and MERS (90, 91).
T254 14449-14657 Sentence denotes Almost half of the MERS-CoV cases reported in Saudi Arabia are of secondary origin that occurred through contact with infected asymptomatic or symptomatic individuals through human-to-human transmission (92).
T255 14658-14778 Sentence denotes The occurrence of superspreading events in the COVID-19 outbreak cannot be ruled out until its possibility is evaluated.
T256 14779-14879 Sentence denotes Like SARS and MERS, COVID-19 can also infect the lower respiratory tract, with milder symptoms (27).
T257 14880-15051 Sentence denotes The basic reproduction number of COVID-19 has been found to be in the range of 2.8 to 3.3 based on real-time reports and 3.2 to 3.9 based on predicted infected cases (84).
T258 15053-15101 Sentence denotes Coronaviruses in Humans—SARS, MERS, and COVID-19
T259 15102-15308 Sentence denotes Coronavirus infection in humans is commonly associated with mild to severe respiratory diseases, with high fever, severe inflammation, cough, and internal organ dysfunction that can even lead to death (92).
T260 15309-15378 Sentence denotes Most of the identified coronaviruses cause the common cold in humans.
T261 15379-15493 Sentence denotes However, this changed when SARS-CoV was identified, paving the way for severe forms of the disease in humans (22).
T262 15494-15717 Sentence denotes Our previous experience with the outbreaks of other coronaviruses, like SARS and MERS, suggests that the mode of transmission in COVID-19 as mainly human-to-human transmission via direct contact, droplets, and fomites (25).
T263 15718-15939 Sentence denotes Recent studies have demonstrated that the virus could remain viable for hours in aerosols and up to days on surfaces; thus, aerosol and fomite contamination could play potent roles in the transmission of SARS-CoV-2 (257).
T264 15940-16029 Sentence denotes The immune response against coronavirus is vital to control and get rid of the infection.
T265 16030-16172 Sentence denotes However, maladjusted immune responses may contribute to the immunopathology of the disease, resulting in impairment of pulmonary gas exchange.
T266 16173-16342 Sentence denotes Understanding the interaction between CoVs and host innate immune systems could enlighten our understanding of the lung inflammation associated with this infection (24).
T267 16343-16563 Sentence denotes SARS is a viral respiratory disease caused by a formerly unrecognized animal CoV that originated from the wet markets in southern China after adapting to the human host, thereby enabling transmission between humans (90).
T268 16564-16667 Sentence denotes The SARS outbreak reported in 2002 to 2003 had 8,098 confirmed cases with 774 total deaths (9.6%) (93).
T269 16668-16755 Sentence denotes The outbreak severely affected the Asia Pacific region, especially mainland China (94).
T270 16756-16977 Sentence denotes Even though the case fatality rate (CFR) of SARS-CoV-2 (COVID-19) is lower than that of SARS-CoV, there exists a severe concern linked to this outbreak due to its epidemiological similarity to influenza viruses (95, 279).
T271 16978-17047 Sentence denotes This can fail the public health system, resulting in a pandemic (96).
T272 17048-17145 Sentence denotes MERS is another respiratory disease that was first reported in Saudi Arabia during the year 2012.
T273 17146-17201 Sentence denotes The disease was found to have a CFR of around 35% (97).
T274 17202-17340 Sentence denotes The analysis of available data sets suggests that the incubation period of SARS-CoV-2, SARS-CoV, and MERS-CoV is in almost the same range.
T275 17341-17404 Sentence denotes The longest predicted incubation time of SARS-CoV-2 is 14 days.
T276 17405-17500 Sentence denotes Hence, suspected individuals are isolated for 14 days to avoid the risk of further spread (98).
T277 17501-17771 Sentence denotes Even though a high similarity has been reported between the genome sequence of the new coronavirus (SARS-CoV-2) and SARS-like CoVs, the comparative analysis recognized a furin-like cleavage site in the SARS-CoV-2 S protein that is missing from other SARS-like CoVs (99).
T278 17772-17949 Sentence denotes The furin-like cleavage site is expected to play a role in the life cycle of the virus and disease pathogenicity and might even act as a therapeutic target for furin inhibitors.
T279 17950-18153 Sentence denotes The highly contagious nature of SARS-CoV-2 compared to that of its predecessors might be the result of a stabilizing mutation that occurred in the endosome-associated-protein-like domain of nsp2 protein.
T280 18154-18333 Sentence denotes Similarly, the destabilizing mutation near the phosphatase domain of nsp3 proteins in SARS-CoV-2 could indicate a potential mechanism that differentiates it from other CoVs (100).
T281 18334-18505 Sentence denotes Even though the CFR reported for COVID-19 is meager compared to those of the previous SARS and MERS outbreaks, it has caused more deaths than SARS and MERS combined (101).
T282 18506-18731 Sentence denotes Possibly related to the viral pathogenesis is the recent finding of an 832-nucleotide (nt) deletion in ORF8, which appears to reduce the replicative fitness of the virus and leads to attenuated phenotypes of SARS-CoV-2 (256).
T283 18732-18897 Sentence denotes Coronavirus is the most prominent example of a virus that has crossed the species barrier twice from wild animals to humans during SARS and MERS outbreaks (79, 102).
T284 18898-19026 Sentence denotes The possibility of crossing the species barrier for the third time has also been suspected in the case of SARS-CoV-2 (COVID-19).
T285 19027-19124 Sentence denotes Bats are recognized as a possible natural reservoir host of both SARS-CoV and MERS-CoV infection.
T286 19125-19253 Sentence denotes In contrast, the possible intermediary host is the palm civet for SARS-CoV and the dromedary camel for MERS-CoV infection (102).
T287 19254-19323 Sentence denotes Bats are considered the ancestral hosts for both SARS and MERS (103).
T288 19324-19426 Sentence denotes Bats are also considered the reservoir host of human coronaviruses like HCoV-229E and HCoV-NL63 (104).
T289 19427-19625 Sentence denotes In the case of COVID-19, there are two possibilities for primary transmission: it can be transmitted either through intermediate hosts, similar to that of SARS and MERS, or directly from bats (103).
T290 19626-19889 Sentence denotes The emergence paradigm put forward in the SARS outbreak suggests that SARS-CoV originated from bats (reservoir host) and later jumped to civets (intermediate host) and incorporated changes within the receptor-binding domain (RBD) to improve binding to civet ACE2.
T291 19890-20048 Sentence denotes This civet-adapted virus, during their subsequent exposure to humans at live markets, promoted further adaptations that resulted in the epidemic strain (104).
T292 20049-20144 Sentence denotes Transmission can also occur directly from the reservoir host to humans without RBD adaptations.
T293 20145-20335 Sentence denotes The bat coronavirus that is currently in circulation maintains specific “poised” spike proteins that facilitate human infection without the requirement of any mutations or adaptations (105).
T294 20336-20437 Sentence denotes Altogether, different species of bats carry a massive number of coronaviruses around the world (106).
T295 20438-20646 Sentence denotes The high plasticity in receptor usage, along with the feasibility of adaptive mutation and recombination, may result in frequent interspecies transmission of coronavirus from bats to animals and humans (106).
T296 20647-20760 Sentence denotes The pathogenesis of most bat coronaviruses is unknown, as most of these viruses are not isolated and studied (4).
T297 20761-20857 Sentence denotes Hedgehog coronavirus HKU31, a Betacoronavirus, has been identified from amur hedgehogs in China.
T298 20858-20969 Sentence denotes Studies show that hedgehogs are the reservoir of Betacoronavirus, and there is evidence of recombination (107).
T299 20970-21163 Sentence denotes The current scientific evidence available on MERS infection suggests that the significant reservoir host, as well as the animal source of MERS infection in humans, is the dromedary camels (97).
T300 21164-21349 Sentence denotes The infected dromedary camels may not show any visible signs of infection, making it challenging to identify animals actively excreting MERS-CoV that has the potential to infect humans.
T301 21350-21484 Sentence denotes However, they may shed MERS-CoV through milk, urine, feces, and nasal and eye discharge and can also be found in the raw organs (108).
T302 21485-21727 Sentence denotes In a study conducted to evaluate the susceptibility of animal species to MERS-CoV infection, llamas and pigs were found to be susceptible, indicating the possibility of MERS-CoV circulation in animal species other than dromedary camels (109).
T303 21728-21943 Sentence denotes Following the outbreak of SARS in China, SARS-CoV-like viruses were isolated from Himalayan palm civets (Paguma larvata) and raccoon dogs (Nyctereutes procyonoides) found in a live-animal market in Guangdong, China.
T304 21944-22091 Sentence denotes The animal isolates obtained from the live-animal market retained a 29-nucleotide sequence that was not present in most of the human isolates (78).
T305 22092-22193 Sentence denotes These findings were critical in identifying the possibility of interspecies transmission in SARS-CoV.
T306 22194-22341 Sentence denotes The higher diversity and prevalence of bat coronaviruses in this region compared to those in previous reports indicate a host/pathogen coevolution.
T307 22342-22462 Sentence denotes SARS-like coronaviruses also have been found circulating in the Chinese horseshoe bat (Rhinolophus sinicus) populations.
T308 22463-22689 Sentence denotes The in vitro and in vivo studies carried out on the isolated virus confirmed that there is a potential risk for the reemergence of SARS-CoV infection from the viruses that are currently circulating in the bat population (105).