LitCovid-sentences  

PMC:7405836 / 14877-17074 JSONTXT 9 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T99 0-102 Sentence denotes Furthermore, it acts as a critical factor for tissue tropism and the determination of host range (45).
T100 103-221 Sentence denotes Notably, S protein is one of the vital immunodominant proteins of CoVs capable of inducing host immune responses (45).
T101 222-338 Sentence denotes The ectodomains in all CoVs S proteins have similar domain organizations, divided into two subunits, S1 and S2 (43).
T102 339-436 Sentence denotes The first one, S1, helps in host receptor binding, while the second one, S2, accounts for fusion.
T103 437-557 Sentence denotes The former (S1) is further divided into two subdomains, namely, the N-terminal domain (NTD) and C-terminal domain (CTD).
T104 558-673 Sentence denotes Both of these subdomains act as receptor-binding domains, interacting efficiently with various host receptors (45).
T105 674-727 Sentence denotes The S1 CTD contains the receptor-binding motif (RBM).
T106 728-831 Sentence denotes In each coronavirus spike protein, the trimeric S1 locates itself on top of the trimeric S2 stalk (45).
T107 832-973 Sentence denotes Recently, structural analyses of the S proteins of COVID-19 have revealed 27 amino acid substitutions within a 1,273-amino-acid stretch (16).
T108 974-1114 Sentence denotes Six substitutions are located in the RBD (amino acids 357 to 528), while four substitutions are in the RBM at the CTD of the S1 domain (16).
T109 1115-1262 Sentence denotes Of note, no amino acid change is seen in the RBM, which binds directly to the angiotensin-converting enzyme-2 (ACE2) receptor in SARS-CoV (16, 46).
T110 1263-1370 Sentence denotes At present, the main emphasis is knowing how many differences would be required to change the host tropism.
T111 1371-1501 Sentence denotes Sequence comparison revealed 17 nonsynonymous changes between the early sequence of SARS-CoV-2 and the later isolates of SARS-CoV.
T112 1502-1694 Sentence denotes The changes were found scattered over the genome of the virus, with nine substitutions in ORF1ab, ORF8 (4 substitutions), the spike gene (3 substitutions), and ORF7a (single substitution) (4).
T113 1695-1859 Sentence denotes Notably, the same nonsynonymous changes were found in a familial cluster, indicating that the viral evolution happened during person-to-person transmission (4, 47).
T114 1860-1992 Sentence denotes Such adaptive evolution events are frequent and constitute a constantly ongoing process once the virus spreads among new hosts (47).
T115 1993-2197 Sentence denotes Even though no functional changes occur in the virus associated with this adaptive evolution, close monitoring of the viral mutations that occur during subsequent human-to-human transmission is warranted.