LitCovid-sentences  

PMC:7405836 / 14358-17074 JSONTXT 10 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T94 0-14 Sentence denotes S Glycoprotein
T95 15-101 Sentence denotes Coronavirus S protein is a large, multifunctional class I viral transmembrane protein.
T96 102-268 Sentence denotes The size of this abundant S protein varies from 1,160 amino acids (IBV, infectious bronchitis virus, in poultry) to 1,400 amino acids (FCoV, feline coronavirus) (43).
T97 269-364 Sentence denotes It lies in a trimer on the virion surface, giving the virion a corona or crown-like appearance.
T98 365-518 Sentence denotes Functionally it is required for the entry of the infectious virion particles into the cell through interaction with various host cellular receptors (44).
T99 519-621 Sentence denotes Furthermore, it acts as a critical factor for tissue tropism and the determination of host range (45).
T100 622-740 Sentence denotes Notably, S protein is one of the vital immunodominant proteins of CoVs capable of inducing host immune responses (45).
T101 741-857 Sentence denotes The ectodomains in all CoVs S proteins have similar domain organizations, divided into two subunits, S1 and S2 (43).
T102 858-955 Sentence denotes The first one, S1, helps in host receptor binding, while the second one, S2, accounts for fusion.
T103 956-1076 Sentence denotes The former (S1) is further divided into two subdomains, namely, the N-terminal domain (NTD) and C-terminal domain (CTD).
T104 1077-1192 Sentence denotes Both of these subdomains act as receptor-binding domains, interacting efficiently with various host receptors (45).
T105 1193-1246 Sentence denotes The S1 CTD contains the receptor-binding motif (RBM).
T106 1247-1350 Sentence denotes In each coronavirus spike protein, the trimeric S1 locates itself on top of the trimeric S2 stalk (45).
T107 1351-1492 Sentence denotes Recently, structural analyses of the S proteins of COVID-19 have revealed 27 amino acid substitutions within a 1,273-amino-acid stretch (16).
T108 1493-1633 Sentence denotes Six substitutions are located in the RBD (amino acids 357 to 528), while four substitutions are in the RBM at the CTD of the S1 domain (16).
T109 1634-1781 Sentence denotes Of note, no amino acid change is seen in the RBM, which binds directly to the angiotensin-converting enzyme-2 (ACE2) receptor in SARS-CoV (16, 46).
T110 1782-1889 Sentence denotes At present, the main emphasis is knowing how many differences would be required to change the host tropism.
T111 1890-2020 Sentence denotes Sequence comparison revealed 17 nonsynonymous changes between the early sequence of SARS-CoV-2 and the later isolates of SARS-CoV.
T112 2021-2213 Sentence denotes The changes were found scattered over the genome of the virus, with nine substitutions in ORF1ab, ORF8 (4 substitutions), the spike gene (3 substitutions), and ORF7a (single substitution) (4).
T113 2214-2378 Sentence denotes Notably, the same nonsynonymous changes were found in a familial cluster, indicating that the viral evolution happened during person-to-person transmission (4, 47).
T114 2379-2511 Sentence denotes Such adaptive evolution events are frequent and constitute a constantly ongoing process once the virus spreads among new hosts (47).
T115 2512-2716 Sentence denotes Even though no functional changes occur in the virus associated with this adaptive evolution, close monitoring of the viral mutations that occur during subsequent human-to-human transmission is warranted.