PMC:7405836 / 136992-139933 JSONTXT 10 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T918 0-18 Sentence denotes CONCLUDING REMARKS
T919 19-262 Sentence denotes Several years after the global SARS epidemic, the current SARS-CoV-2/COVID-19 pandemic has served as a reminder of how novel pathogens can rapidly emerge and spread through the human population and eventually cause severe public health crises.
T920 263-420 Sentence denotes Further research should be conducted to establish animal models for SARS-CoV-2 to investigate replication, transmission dynamics, and pathogenesis in humans.
T921 421-520 Sentence denotes This may help develop and evaluate potential therapeutic strategies against zoonotic CoV epidemics.
T922 521-688 Sentence denotes Present trends suggest the occurrence of future outbreaks of CoVs due to changes in the climate, and ecological conditions may be associated with human-animal contact.
T923 689-1060 Sentence denotes Live-animal markets, such as the Huanan South China Seafood Market, represent ideal conditions for interspecies contact of wildlife with domestic birds, pigs, and mammals, which substantially increases the probability of interspecies transmission of CoV infections and could result in high risks to humans due to adaptive genetic recombination in these viruses (323–325).
T924 1061-1160 Sentence denotes The COVID-19-associated symptoms are fever, cough, expectoration, headache, and myalgia or fatigue.
T925 1161-1325 Sentence denotes Individuals with asymptomatic and atypical clinical manifestations were also identified recently, further adding to the complexity of disease transmission dynamics.
T926 1326-1463 Sentence denotes Atypical clinical manifestations may only express symptoms such as fatigue instead of respiratory signs such as fever, cough, and sputum.
T927 1464-1636 Sentence denotes In such cases, the clinician must be vigilant for the possible occurrence of asymptomatic and atypical clinical manifestations to avoid the possibility of missed diagnoses.
T928 1637-1701 Sentence denotes The present outbreak caused by SARS-CoV-2 was, indeed, expected.
T929 1702-1785 Sentence denotes Similar to previous outbreaks, the current pandemic also will be contained shortly.
T930 1786-1951 Sentence denotes However, the real question is, how are we planning to counter the next zoonotic CoV epidemic that is likely to occur within the next 5 to 10 years or perhaps sooner?
T931 1952-2178 Sentence denotes Our knowledge of most of the bat CoVs is scarce, as these viruses have not been isolated and studied, and extensive studies on such viruses are typically only conducted when they are associated with specific disease outbreaks.
T932 2179-2396 Sentence denotes The next step following the control of the COVID-19 outbreak in China should be focused on screening, identification, isolation, and characterization of CoVs present in wildlife species of China, particularly in bats.
T933 2397-2523 Sentence denotes Both in vitro and in vivo studies (using suitable animal models) should be conducted to evaluate the risk of future epidemics.
T934 2524-2627 Sentence denotes Presently, licensed antiviral drugs or vaccines against SARS-CoV, MERS-CoV, and SARS-CoV-2 are lacking.
T935 2628-2807 Sentence denotes However, advances in designing antiviral drugs and vaccines against several other emerging diseases will help develop suitable therapeutic agents against COVID-19 in a short time.
T936 2808-2941 Sentence denotes Until then, we must rely exclusively on various control and prevention measures to prevent this new disease from becoming a pandemic.