| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T816 |
0-116 |
Sentence |
denotes |
The SARS-CoV S2 subunit has a significant function in mediating virus fusion that provides entry into the host cell. |
| T817 |
117-295 |
Sentence |
denotes |
Heptad repeat 1 (HR1) and heptad repeat 2 (HR2) can interact and form a six-helix bundle that brings the viral and cellular membranes in close proximity, facilitating its fusion. |
| T818 |
296-432 |
Sentence |
denotes |
The sequence alignment study conducted between COVID-19 and SARS-CoV identified that the S2 subunits are highly conserved in these CoVs. |
| T819 |
433-516 |
Sentence |
denotes |
The HR1 and HR2 domains showed 92.6% and 100% overall identity, respectively (210). |
| T820 |
517-634 |
Sentence |
denotes |
From these findings, we can confirm the significance of COVID-19 HR1 and HR2 and their vital role in host cell entry. |
| T821 |
635-757 |
Sentence |
denotes |
Hence, fusion inhibitors target the HR1 domain of S protein, thereby preventing viral fusion and entry into the host cell. |
| T822 |
758-852 |
Sentence |
denotes |
This is another potential therapeutic strategy that can be used in the management of COVID-19. |
| T823 |
853-1017 |
Sentence |
denotes |
Other than the specific therapy directed against COVID-19, general treatments play a vital role in the enhancement of host immune responses against the viral agent. |
| T824 |
1018-1134 |
Sentence |
denotes |
Inadequate nutrition is linked to the weakening of the host immune response, making the individual more susceptible. |
| T825 |
1135-1278 |
Sentence |
denotes |
The role played by nutrition in disease susceptibility should be measured by evaluating the nutritional status of patients with COVID-19 (205). |
