LitCovid-sentences  

PMC:7405836 / 117881-122367 JSONTXT 10 Projects

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Id Subject Object Predicate Lexical cue
T796 0-28 Sentence denotes Potential Therapeutic Agents
T797 29-543 Sentence denotes Potent therapeutics to combat SARS-CoV-2 infection include virus binding molecules, molecules or inhibitors targeting particular enzymes implicated in replication and transcription process of the virus, helicase inhibitors, vital viral proteases and proteins, protease inhibitors of host cells, endocytosis inhibitors, short interfering RNA (siRNA), neutralizing antibodies, MAbs against the host receptor, MAbs interfering with the S1 RBD, antiviral peptide aimed at S2, and natural drugs/medicines (7, 166, 186).
T798 544-763 Sentence denotes The S protein acts as the critical target for developing CoV antivirals, like inhibitors of S protein and S cleavage, neutralizing antibodies, RBD-ACE2 blockers, siRNAs, blockers of the fusion core, and proteases (168).
T799 764-859 Sentence denotes All of these therapeutic approaches have revealed both in vitro and in vivo anti-CoV potential.
T800 860-1009 Sentence denotes Although in vitro research carried out with these therapeutics showed efficacy, most need appropriate support from randomized animal or human trials.
T801 1010-1127 Sentence denotes Therefore, they might be of limited applicability and require trials against SARS-CoV-2 to gain practical usefulness.
T802 1128-1275 Sentence denotes The binding of SARS-CoV-2 with ACE2 leads to the exacerbation of pneumonia as a consequence of the imbalance in the renin-angiotensin system (RAS).
T803 1276-1434 Sentence denotes The virus-induced pulmonary inflammatory responses may be reduced by the administration of ACE inhibitors (ACEI) and angiotensin type-1 receptor (AT1R) (207).
T804 1435-1559 Sentence denotes Several investigations have suggested the use of small-molecule inhibitors for the potential control of SARS-CoV infections.
T805 1560-1762 Sentence denotes Drugs of the FDA-approved compound library were screened to identify four small-molecule inhibitors of MERS-CoV (chlorpromazine, chloroquine, loperamide, and lopinavir) that inhibited viral replication.
T806 1763-1821 Sentence denotes These compounds also hinder SARS-CoV and human CoVs (208).
T807 1822-1999 Sentence denotes Therapeutic strategies involving the use of specific antibodies or compounds that neutralize cytokines and their receptors will help to restrain the host inflammatory responses.
T808 2000-2129 Sentence denotes Such drugs acting specifically in the respiratory tract will help to reduce virus-triggered immune pathologies in COVID-19 (209).
T809 2130-2304 Sentence denotes The later stages of coronavirus-induced inflammatory cascades are characterized by the release of proinflammatory interleukin-1 (IL-1) family members, such as IL-1 and IL-33.
T810 2305-2483 Sentence denotes Hence, there exists a possibility that the inflammation associated with coronavirus can be inhibited by utilizing anti-inflammatory cytokines that belong to the IL-1 family (92).
T811 2484-2615 Sentence denotes It has also been suggested that the actin protein is the host factor that is involved in cell entry and pathogenesis of SARS-CoV-2.
T812 2616-2776 Sentence denotes Hence, those drugs that modulate the biological activity of this protein, like ibuprofen, might have some therapeutic application in managing the disease (174).
T813 2777-2915 Sentence denotes The plasma angiotensin 2 level was found to be markedly elevated in COVID-19 infection and was correlated with viral load and lung injury.
T814 2916-3019 Sentence denotes Hence, drugs that block angiotensin receptors may have potential for treating COVID-19 infection (121).
T815 3020-3207 Sentence denotes A scientist from Germany, named Rolf Hilgenfeld, has been working on the identification of drugs for the treatment of coronaviral infection since the time of the first SARS outbreak (19).
T816 3208-3324 Sentence denotes The SARS-CoV S2 subunit has a significant function in mediating virus fusion that provides entry into the host cell.
T817 3325-3503 Sentence denotes Heptad repeat 1 (HR1) and heptad repeat 2 (HR2) can interact and form a six-helix bundle that brings the viral and cellular membranes in close proximity, facilitating its fusion.
T818 3504-3640 Sentence denotes The sequence alignment study conducted between COVID-19 and SARS-CoV identified that the S2 subunits are highly conserved in these CoVs.
T819 3641-3724 Sentence denotes The HR1 and HR2 domains showed 92.6% and 100% overall identity, respectively (210).
T820 3725-3842 Sentence denotes From these findings, we can confirm the significance of COVID-19 HR1 and HR2 and their vital role in host cell entry.
T821 3843-3965 Sentence denotes Hence, fusion inhibitors target the HR1 domain of S protein, thereby preventing viral fusion and entry into the host cell.
T822 3966-4060 Sentence denotes This is another potential therapeutic strategy that can be used in the management of COVID-19.
T823 4061-4225 Sentence denotes Other than the specific therapy directed against COVID-19, general treatments play a vital role in the enhancement of host immune responses against the viral agent.
T824 4226-4342 Sentence denotes Inadequate nutrition is linked to the weakening of the host immune response, making the individual more susceptible.
T825 4343-4486 Sentence denotes The role played by nutrition in disease susceptibility should be measured by evaluating the nutritional status of patients with COVID-19 (205).