LitCovid-sentences  

PMC:7405836 / 109038-110552 JSONTXT 10 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T743 0-167 Sentence denotes Chloroquine is an antimalarial drug known to possess antiviral activity due to its ability to block virus-cell fusion by raising the endosomal pH necessary for fusion.
T744 168-313 Sentence denotes It also interferes with virus-receptor binding by interfering with the terminal glycosylation of SARS-CoV cellular receptors, such as ACE2 (196).
T745 314-521 Sentence denotes In a recent multicenter clinical trial that was conducted in China, chloroquine phosphate was found to exhibit both efficacy and safety in the therapeutic management of SARS-CoV-2-associated pneumonia (197).
T746 522-655 Sentence denotes This drug is already included in the treatment guidelines issued by the National Health Commission of the People’s Republic of China.
T747 656-766 Sentence denotes The preliminary clinical trials using hydroxychloroquine, another aminoquinoline drug, gave promising results.
T748 767-882 Sentence denotes The COVID-19 patients received 600 mg of hydroxychloroquine daily along with azithromycin as a single-arm protocol.
T749 883-966 Sentence denotes This protocol was found to be associated with a noteworthy reduction in viral load.
T750 967-1123 Sentence denotes Finally, it resulted in a complete cure (271); however, the study comprised a small population and, hence, the possibility of misinterpretation could arise.
T751 1124-1332 Sentence denotes However, in another case study, the authors raised concerns over the efficacy of hydroxychloroquine-azithromycin in the treatment of COVID-19 patients, since no observable effect was seen when they were used.
T752 1333-1428 Sentence denotes In some cases, the treatment was discontinued due to the prolongation of the QT interval (307).
T753 1429-1514 Sentence denotes Hence, further randomized clinical trials are required before concluding this matter.