| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T736 |
0-237 |
Sentence |
denotes |
Remdesivir, a novel nucleotide analog prodrug, was developed for treating Ebola virus disease (EVD), and it was also found to inhibit the replication of SARS-CoV and MERS-CoV in primary human airway epithelial cell culture systems (195). |
| T737 |
238-349 |
Sentence |
denotes |
Recently, in vitro study has proven that remdesivir has better antiviral activity than lopinavir and ritonavir. |
| T738 |
350-631 |
Sentence |
denotes |
Further, in vivo studies conducted in mice also identified that treatment with remdesivir improved pulmonary function and reduced viral loads and lung pathology both in prophylactic and therapeutic regimens compared to lopinavir/ritonavir-IFN-γ treatment in MERS-CoV infection (8). |
| T739 |
632-777 |
Sentence |
denotes |
Remdesivir also inhibits a diverse range of coronaviruses, including circulating human CoV, zoonotic bat CoV, and prepandemic zoonotic CoV (195). |
| T740 |
778-885 |
Sentence |
denotes |
Remdesivir is also considered the only therapeutic drug that significantly reduces pulmonary pathology (8). |
| T741 |
886-1024 |
Sentence |
denotes |
All these findings indicate that remdesivir has to be further evaluated for its efficacy in the treatment of COVID-19 infection in humans. |
| T742 |
1025-1160 |
Sentence |
denotes |
The broad-spectrum activity exhibited by remdesivir will help control the spread of disease in the event of a new coronavirus outbreak. |
