| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T714 |
0-140 |
Sentence |
denotes |
Repurposed broad-spectrum antiviral drugs having proven uses against other viral pathogens can be employed for SARS-CoV-2-infected patients. |
| T715 |
141-288 |
Sentence |
denotes |
These possess benefits of easy accessibility and recognized pharmacokinetic and pharmacodynamic activities, stability, doses, and side effects (9). |
| T716 |
289-436 |
Sentence |
denotes |
Repurposed drugs have been studied for treating CoV infections, like lopinavir/ritonavir, and interferon-1β revealed in vitro anti-MERS-CoV action. |
| T717 |
437-662 |
Sentence |
denotes |
The in vivo experiment carried out in the nonhuman primate model of common marmosets treated with lopinavir/ritonavir and interferon beta showed superior protective results in treated animals than in the untreated ones (190). |
| T718 |
663-757 |
Sentence |
denotes |
A combination of these drugs is being evaluated to treat MERS in humans (MIRACLE trial) (191). |
| T719 |
758-941 |
Sentence |
denotes |
These two protease inhibitors (lopinavir and ritonavir), in combination with ribavirin, gave encouraging clinical outcomes in SARS patients, suggesting their therapeutic values (165). |
| T720 |
942-1229 |
Sentence |
denotes |
However, in the current scenario, due to the lack of specific therapeutic agents against SARS-CoV-2, hospitalized patients confirmed for the disease are given supportive care, like oxygen and fluid therapy, along with antibiotic therapy for managing secondary bacterial infections (192). |
| T721 |
1230-1479 |
Sentence |
denotes |
Patients with novel coronavirus or COVID-19 pneumonia who are mechanically ventilated often require sedatives, analgesics, and even muscle relaxation drugs to prevent ventilator-related lung injury associated with human-machine incoordination (122). |
| T722 |
1480-1752 |
Sentence |
denotes |
The result obtained from a clinical study of four patients infected with COVID-19 claimed that combination therapy using lopinavir/ritonavir, arbidol, and Shufeng Jiedu capsules (traditional Chinese medicine) was found to be effective in managing COVID-19 pneumonia (193). |
| T723 |
1753-1902 |
Sentence |
denotes |
It is difficult to evaluate the therapeutic potential of a drug or a combination of drugs for managing a disease based on such a limited sample size. |
| T724 |
1903-2070 |
Sentence |
denotes |
Before choosing the ideal therapeutic agent for the management of COVID-19, randomized clinical control studies should be performed with a sufficient study population. |
