Id |
Subject |
Object |
Predicate |
Lexical cue |
T468 |
0-98 |
Sentence |
denotes |
The authors thank patients and blood donors, their families and surrogates, and medical personnel. |
T469 |
99-110 |
Sentence |
denotes |
We thank L. |
T470 |
111-148 |
Sentence |
denotes |
Bershaw for recruitment of HD and RD. |
T471 |
149-160 |
Sentence |
denotes |
We thank S. |
T472 |
161-210 |
Sentence |
denotes |
Ngiow for essential infrastructure support and C. |
T473 |
211-287 |
Sentence |
denotes |
Ash for donation of computational equipment and design of schematic figures. |
T474 |
288-366 |
Sentence |
denotes |
We thank the Wherry lab for discussions and critically reading the manuscript. |
T475 |
367-375 |
Sentence |
denotes |
Funding: |
T476 |
376-607 |
Sentence |
denotes |
This work was supported by the University of Pennsylvania Institute for Immunology Glick COVID-19 research award (MRB), NIH AI105343, AI082630, and the Allen Institute for Immunology (EJW) and NIH grants HL137006 and H137915 (NJM). |
T477 |
608-654 |
Sentence |
denotes |
ACH was funded by grant CA230157 from the NIH. |
T478 |
655-693 |
Sentence |
denotes |
DM and JG were funded by T32 CA009140. |
T479 |
694-730 |
Sentence |
denotes |
ZC was funded by NIH grant CA234842. |
T480 |
731-761 |
Sentence |
denotes |
DAO was funded by NHLBI StARR: |
T481 |
762-775 |
Sentence |
denotes |
1R38HL143613. |
T482 |
776-891 |
Sentence |
denotes |
NJM reports funding to her institution from Athersys, Inc., Biomarck, Inc., and the Marcus Foundation for Research. |
T483 |
892-950 |
Sentence |
denotes |
JRG is a Cancer Research Institute-Mark Foundation Fellow. |
T484 |
951-1119 |
Sentence |
denotes |
JRG, JEW, CA, AH, and EJW are supported by the Parker Institute for Cancer Immunotherapy which supports the Cancer Immunology program at the University of Pennsylvania. |
T485 |
1120-1165 |
Sentence |
denotes |
The authors declare no conflicts of interest. |
T486 |
1166-1276 |
Sentence |
denotes |
Author contributions: DM, NJM, MJB, and EJW conceived the project; DM, JRG, AEB, and EJW designed experiments. |
T487 |
1277-1453 |
Sentence |
denotes |
NM conceived the clinical cohort, obtained clinical samples and metadata from COVID-19 patients and provided clinical input; OK and JD provided clinical samples from HD and RD. |
T488 |
1454-1520 |
Sentence |
denotes |
AEB and KD coordinated clinical sample procurement and processing. |
T489 |
1521-1590 |
Sentence |
denotes |
DM, ARG, LKC, MBP, NH, JK, AP, FC, and SFL processed patient samples. |
T490 |
1591-1718 |
Sentence |
denotes |
DM, ZC, and YJH stained and JEW acquired flow cytometry samples; JRG, AEB, and KN performed downstream flow cytometry analysis. |
T491 |
1719-1756 |
Sentence |
denotes |
HR and SCC performed qRT-PCR of PBMC. |
T492 |
1757-1803 |
Sentence |
denotes |
DM, SFL, and FC performed Luminex experiments. |
T493 |
1804-1901 |
Sentence |
denotes |
ECG, EMA, MEW, SG, CPA, MJB, and SEH analyzed COVID-19 patient plasma and provided antibody data. |
T494 |
1902-2036 |
Sentence |
denotes |
ACH and LAV provided additional clinical data; CA compiled and JRG, DO, and CA analyzed clinical metadata with input from ACH and LAV. |
T495 |
2037-2161 |
Sentence |
denotes |
JRG, DAO, SM, and EJW designed data analysis and JRG, ARG, CA, DAO, and SM performed computational and statistical analyses. |
T496 |
2162-2205 |
Sentence |
denotes |
DM, JRG, ARG, CA, and DAO compiled figures. |
T497 |
2206-2269 |
Sentence |
denotes |
LKC, MBP, SA, ACH, LAV, NJM and MB provided intellectual input. |
T498 |
2270-2355 |
Sentence |
denotes |
DM, AEB, ARG, JEW, and EJW wrote the manuscript; all authors reviewed the manuscript. |
T499 |
2356-2513 |
Sentence |
denotes |
Competing interests: E.J.W. has consulting agreements with and/or is on the scientific advisory board for Merck, Roche, Pieris, Elstar, and Surface Oncology. |
T500 |
2514-2578 |
Sentence |
denotes |
E.J.W. is a founder of Surface Oncology and Arsenal Biosciences. |
T501 |
2579-2660 |
Sentence |
denotes |
E.J.W. has a patent licensing agreement on the PD-1 pathway with Roche/Genentech. |
T502 |
2661-2823 |
Sentence |
denotes |
E.J.W. is an inventor on a patent (US Patent number 10,370,446) submitted by Emory University that covers the use of PD-1 blockade to treat infections and cancer. |
T503 |
2824-2856 |
Sentence |
denotes |
Data and materials availability: |
T504 |
2857-3035 |
Sentence |
denotes |
Flow Cytometry data collected in this study was deposited to the Human Pancreas Analysis Program (HPAP-RRID:SCR_016202) Database and Cytobank (61) (https://hpap.pmacs.upenn.edu). |
T505 |
3036-3107 |
Sentence |
denotes |
B cell data (https://premium.cytobank.org/cytobank/experiments/308353). |
T506 |
3108-3189 |
Sentence |
denotes |
Non Naive CD4 T cells (https://premium.cytobank.org/cytobank/experiments/308354). |
T507 |
3190-3271 |
Sentence |
denotes |
Non Naive CD8 T cells (https://premium.cytobank.org/cytobank/experiments/308357). |
T508 |
3272-3493 |
Sentence |
denotes |
This work is licensed under a Creative Commons Attribution 4.0 International (CC BY 4.0) license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
T509 |
3494-3577 |
Sentence |
denotes |
To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
T510 |
3578-3779 |
Sentence |
denotes |
This license does not apply to figures/photos/artwork or other content included in the article that is credited to a third party; obtain authorization from the rights holder before using such material. |