PMC:7402624 / 75617-79396 JSONTXT 9 Projects

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Id Subject Object Predicate Lexical cue
T468 0-98 Sentence denotes The authors thank patients and blood donors, their families and surrogates, and medical personnel.
T469 99-110 Sentence denotes We thank L.
T470 111-148 Sentence denotes Bershaw for recruitment of HD and RD.
T471 149-160 Sentence denotes We thank S.
T472 161-210 Sentence denotes Ngiow for essential infrastructure support and C.
T473 211-287 Sentence denotes Ash for donation of computational equipment and design of schematic figures.
T474 288-366 Sentence denotes We thank the Wherry lab for discussions and critically reading the manuscript.
T475 367-375 Sentence denotes Funding:
T476 376-607 Sentence denotes This work was supported by the University of Pennsylvania Institute for Immunology Glick COVID-19 research award (MRB), NIH AI105343, AI082630, and the Allen Institute for Immunology (EJW) and NIH grants HL137006 and H137915 (NJM).
T477 608-654 Sentence denotes ACH was funded by grant CA230157 from the NIH.
T478 655-693 Sentence denotes DM and JG were funded by T32 CA009140.
T479 694-730 Sentence denotes ZC was funded by NIH grant CA234842.
T480 731-761 Sentence denotes DAO was funded by NHLBI StARR:
T481 762-775 Sentence denotes 1R38HL143613.
T482 776-891 Sentence denotes NJM reports funding to her institution from Athersys, Inc., Biomarck, Inc., and the Marcus Foundation for Research.
T483 892-950 Sentence denotes JRG is a Cancer Research Institute-Mark Foundation Fellow.
T484 951-1119 Sentence denotes JRG, JEW, CA, AH, and EJW are supported by the Parker Institute for Cancer Immunotherapy which supports the Cancer Immunology program at the University of Pennsylvania.
T485 1120-1165 Sentence denotes The authors declare no conflicts of interest.
T486 1166-1276 Sentence denotes Author contributions: DM, NJM, MJB, and EJW conceived the project; DM, JRG, AEB, and EJW designed experiments.
T487 1277-1453 Sentence denotes NM conceived the clinical cohort, obtained clinical samples and metadata from COVID-19 patients and provided clinical input; OK and JD provided clinical samples from HD and RD.
T488 1454-1520 Sentence denotes AEB and KD coordinated clinical sample procurement and processing.
T489 1521-1590 Sentence denotes DM, ARG, LKC, MBP, NH, JK, AP, FC, and SFL processed patient samples.
T490 1591-1718 Sentence denotes DM, ZC, and YJH stained and JEW acquired flow cytometry samples; JRG, AEB, and KN performed downstream flow cytometry analysis.
T491 1719-1756 Sentence denotes HR and SCC performed qRT-PCR of PBMC.
T492 1757-1803 Sentence denotes DM, SFL, and FC performed Luminex experiments.
T493 1804-1901 Sentence denotes ECG, EMA, MEW, SG, CPA, MJB, and SEH analyzed COVID-19 patient plasma and provided antibody data.
T494 1902-2036 Sentence denotes ACH and LAV provided additional clinical data; CA compiled and JRG, DO, and CA analyzed clinical metadata with input from ACH and LAV.
T495 2037-2161 Sentence denotes JRG, DAO, SM, and EJW designed data analysis and JRG, ARG, CA, DAO, and SM performed computational and statistical analyses.
T496 2162-2205 Sentence denotes DM, JRG, ARG, CA, and DAO compiled figures.
T497 2206-2269 Sentence denotes LKC, MBP, SA, ACH, LAV, NJM and MB provided intellectual input.
T498 2270-2355 Sentence denotes DM, AEB, ARG, JEW, and EJW wrote the manuscript; all authors reviewed the manuscript.
T499 2356-2513 Sentence denotes Competing interests: E.J.W. has consulting agreements with and/or is on the scientific advisory board for Merck, Roche, Pieris, Elstar, and Surface Oncology.
T500 2514-2578 Sentence denotes E.J.W. is a founder of Surface Oncology and Arsenal Biosciences.
T501 2579-2660 Sentence denotes E.J.W. has a patent licensing agreement on the PD-1 pathway with Roche/Genentech.
T502 2661-2823 Sentence denotes E.J.W. is an inventor on a patent (US Patent number 10,370,446) submitted by Emory University that covers the use of PD-1 blockade to treat infections and cancer.
T503 2824-2856 Sentence denotes Data and materials availability:
T504 2857-3035 Sentence denotes Flow Cytometry data collected in this study was deposited to the Human Pancreas Analysis Program (HPAP-RRID:SCR_016202) Database and Cytobank (61) (https://hpap.pmacs.upenn.edu).
T505 3036-3107 Sentence denotes B cell data (https://premium.cytobank.org/cytobank/experiments/308353).
T506 3108-3189 Sentence denotes Non Naive CD4 T cells (https://premium.cytobank.org/cytobank/experiments/308354).
T507 3190-3271 Sentence denotes Non Naive CD8 T cells (https://premium.cytobank.org/cytobank/experiments/308357).
T508 3272-3493 Sentence denotes This work is licensed under a Creative Commons Attribution 4.0 International (CC BY 4.0) license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
T509 3494-3577 Sentence denotes To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
T510 3578-3779 Sentence denotes This license does not apply to figures/photos/artwork or other content included in the article that is credited to a third party; obtain authorization from the rights holder before using such material.