| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T303 |
0-75 |
Sentence |
denotes |
The T and B cell response to SARS-CoV2 infection remains poorly understood. |
| T304 |
76-227 |
Sentence |
denotes |
Some studies suggest an overaggressive immune response leading to immunopathology (51) whereas others suggest T cell exhaustion or dysfunction (12–14). |
| T305 |
228-354 |
Sentence |
denotes |
Autopsies revealed high virus levels in the respiratory tract and other tissues (52), suggesting ineffective immune responses. |
| T306 |
355-473 |
Sentence |
denotes |
Nevertheless, non-hospitalized subjects who recovered from COVID-19 had evidence of virus-specific T cell memory (53). |
| T307 |
474-627 |
Sentence |
denotes |
SARS-CoV2-specific antibodies are also found in convalescent subjects and patients are currently being treated with convalescent plasma therapy (30, 54). |
| T308 |
628-795 |
Sentence |
denotes |
However, COVID-19 ICU patients have SARS-CoV2-specific antibodies (30), raising the question of why patients with these antibody responses are not controlling disease. |
| T309 |
796-969 |
Sentence |
denotes |
In general, these studies report on single patients or small cohorts and comprehensive deep immune profiling of a large number of COVID-19 hospitalized patients is limiting. |
| T310 |
970-1107 |
Sentence |
denotes |
Such knowledge would address the critical question of whether there is a common profile of immune dysfunction in critically ill patients. |
| T311 |
1108-1246 |
Sentence |
denotes |
Such data would also help guide testing of therapeutics to enhance, inhibit, or otherwise tailor the immune response in COVID-19 patients. |
