LitCovid-sentences  

PMC:7402624 / 26492-28081 JSONTXT 10 Projects

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Id Subject Object Predicate Lexical cue
T159 0-60 Sentence denotes B cell subpopulations were also altered in COVID-19 disease.
T160 61-275 Sentence denotes Whereas naïve B cell frequencies were similar in COVID-19 patients and RD or HD, the frequencies of class-switched (IgD−CD27+) and not-class-switched (IgD+CD27+) memory B cells were significantly reduced (Fig. 4A).
T161 276-387 Sentence denotes Conversely, frequencies of CD27−IgD− B cells and CD27+CD38+ PB were often robustly increased (Fig. 4, A and B).
T162 388-525 Sentence denotes In some cases, PB represented >30% of circulating B cells, similar to levels observed in acute Ebola or Dengue virus infections (42, 43).
T163 526-679 Sentence denotes However, these PB responses were only observed in ~2/3 of patients, with the remaining patients displaying PB frequencies similar to HD and RD (Fig. 4B).
T164 680-811 Sentence denotes KI67 expression was markedly elevated in all B cell subpopulations in COVID-19 patients compared to either control group (Fig. 4C).
T165 812-929 Sentence denotes This observation suggests a role for an antigen-driven response to infection and/or lymphopenia-driven proliferation.
T166 930-1024 Sentence denotes Higher KI67 in PB may reflect recent generation in the COVID-19 patients compared to HD or RD.
T167 1025-1118 Sentence denotes CXCR5 expression was also reduced on all major B cell subsets in COVID-19 patients (Fig. 4D).
T168 1119-1239 Sentence denotes Loss of CXCR5 was not specific to B cells, however, as expression was also decreased on non-naïve CD4 T cells (Fig. 4E).
T169 1240-1462 Sentence denotes Changes in the B cell subsets were not associated with co-infection, immune suppression, or treatment with steroids or other clinical features, though a possible negative association of IL-6 and PB was revealed (fig. S5A).
T170 1463-1589 Sentence denotes These observations suggest that the B cell response phenotype of COVID-19 disease was not simply due to systemic inflammation.