| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T69 |
0-205 |
Sentence |
denotes |
To begin to interrogate immune responses to acute SARS-CoV2 infection, we compared peripheral blood mononuclear cells (PBMC) of COVID-19 patients, RD, and HD subjects using high dimensional flow cytometry. |
| T70 |
206-259 |
Sentence |
denotes |
We first focused on the major lymphocyte populations. |
| T71 |
260-498 |
Sentence |
denotes |
B cell and CD3+ T cell frequencies were decreased in COVID-19 patients compared to HD or RD subjects, reflecting clinical lymphopenia, whereas the relative frequency of non-B and non-T cells was correspondingly elevated (Fig. 1, D and E). |
| T72 |
499-666 |
Sentence |
denotes |
Although a numerical expansion of a non-B, non-T cell type is possible, loss of lymphocytes likely results in an increase in the relative frequency of this population. |
| T73 |
667-760 |
Sentence |
denotes |
This non-B, non-T cell population is also interrogated in more detail in the companion study. |
| T74 |
761-1217 |
Sentence |
denotes |
Examining only CD3 T cells revealed preferential loss of CD8 T cells compared to CD4 T cells (Fig. 1, F and G, and fig. S1D); this pattern was reflected in absolute numbers estimated from the clinical data, where both CD4 and CD8 T cell counts in COVID-19 patients were lower than the clinical reference range, though the effect was more prominent for CD8 T cells (49/61 subjects below normal) than for CD4 T cells (38/61 subjects below normal) (fig. S1E). |
| T75 |
1218-1368 |
Sentence |
denotes |
These findings are consistent with previous reports of lymphopenia during COVID-19 disease (17–20) but highlight a preferential impact on CD8 T cells. |
