LitCovid-sentences  

PMC:7396557 / 73580-79079 JSONTXT 12 Projects

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Id Subject Object Predicate Lexical cue
T545 0-25 Sentence denotes Clinical Research on XBJI
T546 26-313 Sentence denotes Modern clinical studies have shown that XBJI in combination with conventional treatment has therapeutic effects in relevant diseases, such as MERS, human infection with H7N9 avian influenza, CAP, severe pneumonia, systemic inflammatory response syndrome, COPD and sepsis (see Table 3 ).
T547 314-493 Sentence denotes XBJI has been recommended in MERS Diagnosis and Treatment Scheme (Version 2015) and Diagnosis and Treatment Scheme for Human Infection with H7N9 Avian Influenza (Version 1, 2017).
T548 494-662 Sentence denotes Clinical research by Wen Long et al. randomly divided 60 severe COVID-19 patients into routine treatment (n = 20), XBJI 50 ml (n = 20), and XBJI 100 ml (n = 20) groups.
T549 663-835 Sentence denotes On the basis of conventional treatment, XBJI (50 ml) was injected twice a day for 7 days in the XBJI 50 ml group, or 100 ml twice a day for 7 days in the XBJI 100 ml group.
T550 836-972 Sentence denotes After treatment, the white blood cell count (WBC) and lymphocyte count (LYM) of the three groups increased, while CRP and ESR decreased.
T551 973-1103 Sentence denotes Compared with the routine treatment group, the WBC count in the XBJI 100 ml group after treatment significantly increased (×109/L:
T552 1104-1246 Sentence denotes 7.12 ± 0.55 vs. 5.67 ± 0.51, p < 0.05), and the levels of CRP and ESR in the XBJI 50 ml and 100 ml groups significantly decreased [CRP (mg/L):
T553 1247-1297 Sentence denotes 32.3 ± 4.6, 28.0 ± 6.2 vs. 37.3 ± 5.9; ESR (mm/h):
T554 1298-1351 Sentence denotes 45.9 ± 5.7, 40.5 ± 7.4 vs. 55.3 ± 6.6, all p < 0.05].
T555 1352-1502 Sentence denotes Compared with the XBJI 50 ml group, the increase of WBC, and the decrease of CRP and ESR were more significant in the XBJI 100 ml group [WBC (×109/L):
T556 1503-1543 Sentence denotes 7.12 ± 0.55 vs. 5.82 ± 0.49; CRP (mg/L):
T557 1544-1582 Sentence denotes 28.0 ± 6.2 vs. 32.3 ± 4.6; ESR (mm/h):
T558 1583-1624 Sentence denotes 40.5 ± 7.4 vs. 45.9 ± 5.7, all p < 0.05].
T559 1625-1671 Sentence denotes The APACHE II score of three groups decreased.
T560 1672-1871 Sentence denotes In the XBJI 100 ml group, the APACHE II score after treatment was significantly lower than those in the routine treatment and XBJI 50 ml groups (12.3 ± 1.5 vs. 16.5 ± 1.6, 15.9 ± 1.4, both p < 0.05).
T561 1872-2128 Sentence denotes After treatment, the 2019-nCoV nucleic acid test in the three groups partly turned negative: nine cases in the routine treatment group, eight cases in the XBJI 50 ml group and nine cases in the XBJI 100 ml group, with no significant differences (p > 0.05).
T562 2129-2206 Sentence denotes The conditions of patients in the three groups were improved after treatment.
T563 2207-2430 Sentence denotes Eight cases in the routine treatment group were transformed into common type and one case into critical type; nine cases and 12 cases in the XBJI 50 ml and 100 ml groups, respectively, were transformed into the common type.
T564 2431-2557 Sentence denotes Patients in the XBJI 100 ml group improved more obviously than in the XBJI 50 ml and routine treatment groups (both p < 0.05).
T565 2558-2687 Sentence denotes The XBJI injection can effectively improve the inflammatory markers and prognosis of severe COVID-19 patients (Wen et al., 2020).
T566 2688-2934 Sentence denotes Clinical research by Qi Fei et al. showed that, of 80 patients with severe pneumonia, those receiving a combination of XBJI and conventional treatment exhibited reduced levels of blood LDH, α1-acid glycoprotein (α1-AG) and α1-antitrypsin (α1-AT).
T567 2935-3048 Sentence denotes Body temperature was reduced significantly and secretion of TNF-α, IL-6, IL-8, and other cytokines was inhibited.
T568 3049-3152 Sentence denotes The total treatment efficiency was up to 80%, compared to 67.5% in the control group (Qi et al., 2011).
T569 3153-3462 Sentence denotes An RCT study comprised of 33 centers and 710 patients conducted by Yuanlin Song et al. showed that XBJI in combination with conventional treatment significantly improved the primary endpoint, pneumonia severity index, in patients with severe CAP (the control group vs XBJI Group, 46.33% vs 60.78%, p < 0.001).
T570 3463-3713 Sentence denotes There was also significantly reduced mortality in 28 days (24.65% vs 15.87%, p = 0.006), the duration of mechanical ventilation was shortened (11 vs 16.5 d, p = 0.012) and length of stay in ICU was reduced (12 vs 16 d, p = 0.004) (Song et al., 2019).
T571 3714-3969 Sentence denotes Mingjin Zhu et al. conducted a meta-analysis of 12 studies with a total of 860 patients and showed that XBJI in combination with conventional treatment was superior to the treatment group in improving total response rate in patients with severe pneumonia.
T572 3970-4150 Sentence denotes Infectious indicators (WBC, CRP, CPIS) and inflammatory cytokine (IL-6, IL-8, TNF-α) levels were reduced, and the average length of stay in hospital was reduced (Zhu et al., 2014).
T573 4151-4492 Sentence denotes Wei Zhao et al. studied 56 patients with systemic inflammatory response syndrome (SIRS) and found that after 7 d treatment with XBJI in combination with conventional treatment, body temperature, WBC, and acute physiology and chronic health evaluation II (APACHE-II) score improved more significantly compared to the control group (p < 0.05).
T574 4493-4711 Sentence denotes Expression of CD4+, CD4+/CD8+, CD14+/HLA-DR (human leukocyte antigen-DR) increased significantly, and the combination regulated the SIRS immune state and improved systemic status of the patients (Zhao W. et al., 2014).
T575 4712-4899 Sentence denotes Clinical research found that XBJI in combination with conventional treatment lowered TNF-α, CRP, and other inflammatory indicators in AECOPD patients and had a certain therapeutic effect.
T576 4900-5113 Sentence denotes In patients with accompanying SIRS, the combination significantly improved cough, expectoration, shortness of breath, and other clinical symptoms, and shortened hospital stay (Chen et al., 2011; Zhu et al., 2019).
T577 5114-5499 Sentence denotes Meta-analysis by Chengyu Li et al. included sepsis patients from 16 RCTs (total 1,144 cases), and evidence of moderate intensity showed that XBJI in combination with conventional treatment effectively reduced the mortality rate of sepsis patients over 28 d (934/1144, p < 0.00001), APACHE-II score (792/1144, p < 0.00001) and body temperature (362/1144, p < 0.00001) (Li et al., 2018).