LitCovid-sentences  

PMC:7396557 / 64399-66163 JSONTXT 11 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T478 0-44 Sentence denotes Progress of Pharmacological Research on XYPI
T479 45-213 Sentence denotes The main ingredient of XYPI is andrographolide total sulfonate, which is antipyretic, anti-inflammatory, antiviral, antibacterial and immune-regulatory (see Table 3 ).
T480 214-489 Sentence denotes Yang Yu et al. conducted in vivo experiments with XYPI, and discovered that it could significantly protect mice infected with Staphylococcus aureus and Streptococcus pneumoniae, and significantly inhibited citric acid-induced cough frequency in guinea pigs (Yu et al., 2009).
T481 490-652 Sentence denotes Using in vitro experiments, Lu Wang et al. studied the inhibitory effect of XYPI on inflammatory factors released by LPS-stimulated mouse mononuclear macrophages.
T482 653-785 Sentence denotes The results showed that XYPI significantly inhibited the release of inflammatory factors such as TNF-α and IL-6 (Wang et al., 2008).
T483 786-1002 Sentence denotes Yinglan Nie et al. explored the mode of action of XYPI in the treatment of acute lung injury by observing its effect on cytokine content in bronchoalveolar lavage fluid (BALF) following LPS-induced acute lung injury.
T484 1003-1248 Sentence denotes The results showed that XYPI could play an anti-inflammatory role by modulating the balance of pro-inflammatory/anti-inflammatory cytokines and prevent excess anti-inflammatory responses during the course of acute lung injury (Nie et al., 2012).
T485 1249-1349 Sentence denotes Qi Liu et al. observed antiviral activity of XYPI against human rhinovirus-induced mouse infections.
T486 1350-1510 Sentence denotes XYPI significantly reduced the virus titer in trachea-lung tissue homogenate of infected mice, effectively inhibiting proliferation of human rhinovirus in mice.
T487 1511-1701 Sentence denotes Respiratory lesions were alleviated in tested animals, survival rate was improved, there were few adverse reactions, and it was an efficient and safe drug against human rhinovirus infection.
T488 1702-1764 Sentence denotes Its specific mode of action, however, was unclear (Liu, 2015).