LitCovid-sentences  

PMC:7396557 / 63719-70215 JSONTXT 11 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T468 0-56 Sentence denotes Relevant Information on the Clinical Application of XYPI
T469 58-90 Sentence denotes Recommended Therapeutic Regimens
T470 91-214 Sentence denotes XYPI has been recommended in 15 therapeutic regimens of COVID-19 in China (see detailed information in Tables 1 and 2 ).
T471 216-235 Sentence denotes Ingredients of XYPI
T472 236-268 Sentence denotes Andrographolide total sulfonate.
T473 269-336 Sentence denotes Basic information on XYPI is provided in the Supplementary Table .
T474 338-389 Sentence denotes Indications for the Treatment of COVID-19 With XYPI
T475 390-502 Sentence denotes XYPI is used for syndrome of exuberance of internal heat toxin in progressive stage of COVID-19 (critical case).
T476 503-591 Sentence denotes Indicative symptoms are fever, sore throat, cough with yellow phlegm and chest distress.
T477 592-678 Sentence denotes It could also be used to treat viral infection combined with mild bacterial infection.
T478 680-724 Sentence denotes Progress of Pharmacological Research on XYPI
T479 725-893 Sentence denotes The main ingredient of XYPI is andrographolide total sulfonate, which is antipyretic, anti-inflammatory, antiviral, antibacterial and immune-regulatory (see Table 3 ).
T480 894-1169 Sentence denotes Yang Yu et al. conducted in vivo experiments with XYPI, and discovered that it could significantly protect mice infected with Staphylococcus aureus and Streptococcus pneumoniae, and significantly inhibited citric acid-induced cough frequency in guinea pigs (Yu et al., 2009).
T481 1170-1332 Sentence denotes Using in vitro experiments, Lu Wang et al. studied the inhibitory effect of XYPI on inflammatory factors released by LPS-stimulated mouse mononuclear macrophages.
T482 1333-1465 Sentence denotes The results showed that XYPI significantly inhibited the release of inflammatory factors such as TNF-α and IL-6 (Wang et al., 2008).
T483 1466-1682 Sentence denotes Yinglan Nie et al. explored the mode of action of XYPI in the treatment of acute lung injury by observing its effect on cytokine content in bronchoalveolar lavage fluid (BALF) following LPS-induced acute lung injury.
T484 1683-1928 Sentence denotes The results showed that XYPI could play an anti-inflammatory role by modulating the balance of pro-inflammatory/anti-inflammatory cytokines and prevent excess anti-inflammatory responses during the course of acute lung injury (Nie et al., 2012).
T485 1929-2029 Sentence denotes Qi Liu et al. observed antiviral activity of XYPI against human rhinovirus-induced mouse infections.
T486 2030-2190 Sentence denotes XYPI significantly reduced the virus titer in trachea-lung tissue homogenate of infected mice, effectively inhibiting proliferation of human rhinovirus in mice.
T487 2191-2381 Sentence denotes Respiratory lesions were alleviated in tested animals, survival rate was improved, there were few adverse reactions, and it was an efficient and safe drug against human rhinovirus infection.
T488 2382-2444 Sentence denotes Its specific mode of action, however, was unclear (Liu, 2015).
T489 2446-2471 Sentence denotes Clinical Research on XYPI
T490 2472-2651 Sentence denotes XYPI is a broad-spectrum antiviral Chinese patent medicine that is widely used to treat acute URI, viral pneumonia and pulmonary infection in clinical practice with good efficacy.
T491 2652-2872 Sentence denotes Recent studies have discovered that it can also inhibit some viruses and bacteria, and could be used to treat influenza, human infection with H7N9 avian influenza, capillary bronchitis and other diseases (see Table 3 ).
T492 2873-3002 Sentence denotes XYPI has been recommended in China’s Diagnosis and Treatment Scheme for Human Infection with H7N9 Avian Influenza (Version 2017).
T493 3003-3137 Sentence denotes Xiuping Yin et al. used the association rule method to analyze drug combinations, including XYPI in patients with pulmonary infection.
T494 3138-3399 Sentence denotes The results showed that it could play a role as alternative or as a supplement to antibiotics in the treatment of pulmonary infection, but the safety and rationality of its use in drug combinations required further study in clinical practice (Yin et al., 2015).
T495 3400-3603 Sentence denotes Guangming Li et al. conducted a retrospective analysis of 92 patients with viral pneumonia and found that XYPI was more effective than Ribavirin, providing significant improvement of symptoms (Li, 2015).
T496 3604-3774 Sentence denotes Ruihan Qi et al. analyzed the therapeutic effect of XYPI in the treatment of viral pneumonia by systematic evaluation and found that it was more effective than Ribavirin.
T497 3775-3899 Sentence denotes XYPI increased the cure rate, improved signs and symptoms, and reduced the incidence of adverse reactions (Qi et al., 2018).
T498 3900-4027 Sentence denotes Lili Zhang et al. used XYPI in combination with Western medicine to treat severe pneumonia of the elderly in clinical practice.
T499 4028-4290 Sentence denotes The results showed that it significantly shortened the course of disease, improved treatment efficiency, reduced the incidence of antibiotic resistance, reduced occurrence of double infection, improved the prognosis, and reduced mortality (Zhang and Wang, 2015).
T500 4291-4476 Sentence denotes Zhixu Yang et al. observed the clinical effect of XYPI in treating the syndrome of phlegm-heat obstructing lung of severe pneumonia from the perspective of traditional Chinese medicine.
T501 4477-4688 Sentence denotes The results showed significant improvements that included reduced fever, reduced numbers of leukocytes, improved oxygen index, lower clinical pulmonary infection score (CPIS), and reduced pulmonary inflammation.
T502 4689-4826 Sentence denotes It also shortened the duration of mechanical ventilation and length of stay in ICU, and improved the clinical effect (Yang et al., 2014).
T503 4827-4905 Sentence denotes In addition, XYPI has also shown significant efficacy in the treatment of URI.
T504 4906-5114 Sentence denotes Xiaowen Liu et al. conducted a retrospective analysis of 660 patients with acute URI and found that the total response rate in the XYPI treatment group was significantly higher than that of the control group.
T505 5115-5179 Sentence denotes The difference was statistically significant (Liu and Li, 2015).
T506 5181-5205 Sentence denotes Usage and Dosage of XYPI
T507 5206-5233 Sentence denotes 1) Intramuscular injection.
T508 5234-5241 Sentence denotes Adults:
T509 5242-5272 Sentence denotes 50-100 mg, 2 or 3 times a day.
T510 5273-5293 Sentence denotes 2) Intravenous drip.
T511 5294-5301 Sentence denotes Adults:
T512 5302-5368 Sentence denotes 250–500 mg a day, diluted with 0.9% sodium chloride or 5% glucose.
T513 5370-5395 Sentence denotes Adverse Reactions of XYPI
T514 5396-5580 Sentence denotes The main adverse reactions are allergic reaction, damage to the skin, damage to the digestive system, damage to the respiratory system, and general damage to the cardiovascular system.
T515 5581-5754 Sentence denotes These are manifested by rash, itching, shivering, facial blushing, fever, cyanosis, difficulty breathing, nausea, vomiting, palpitations, chest distress, and allergic shock.
T516 5756-5772 Sentence denotes XYPI Precautions
T517 5773-5844 Sentence denotes 1) Use is forbidden in pregnant women and children under 1 year of age.
T518 5845-5899 Sentence denotes Use with caution in the elderly above 75 years of age.
T519 5900-6056 Sentence denotes 2) Use is forbidden in those with a history of allergic or severe adverse reactions to this drug or preparations containing andrographolide total sulfonate.
T520 6057-6266 Sentence denotes 3) Enhanced monitoring is recommended in patients using XYPI for the first time; pay close attention to reactions during administration, especially if discovering abnormalities within 30 min of administration.
T521 6267-6331 Sentence denotes Stop administration immediately and take active rescue measures.
T522 6332-6417 Sentence denotes 4) When used in combination with other injections, XYPI should be administered first.
T523 6418-6496 Sentence denotes Other injections can be infused after flushing or replacing the infusion tube.