LitCovid-sentences  

PMC:7396557 / 12801-28815 JSONTXT 12 Projects

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Id Subject Object Predicate Lexical cue
T119 0-45 Sentence denotes Progress of Pharmacological Research on HXZQC
T120 46-241 Sentence denotes Modern pharmacological studies have found that HXZQC has antiviral, anti-inflammatory, and immune regulatory activities, improves gastrointestinal discomfort and other properties (see Table 3 ).
T121 242-344 Sentence denotes Table 3 Pharmacological functions and clinical research on top 10 CPMs for the treatment of COVID-19.
T122 345-433 Sentence denotes Drug name Pharmacological action Mechanism Clinical application Therapeutic efficacy
T123 434-632 Sentence denotes HXZQC Regulate the immunity and improve the gastroenteric function Inhibits LPS and epithelial barrier disorder, stipulate expression of proinflammatory cytokine of macrophage (Wang et al., 2012).
T124 633-740 Sentence denotes Improve thymus coefficient, spleen coefficient, immunoglobulin G (IgG) level of the mice (Li et al., 2017).
T125 741-894 Sentence denotes Regulates effect of the balance of CD4+ and CD8+ T lymphocytes, and reduction of IL-2, IL-10, IL-1β and TNF-α level (He et al., 2006; Zong et al., 2015).
T126 895-1051 Sentence denotes Improves serum NO level of rats, reduces concentration of 5-HT, and downregulates the level of plasma motilin and colonic somatostatin (Huang et al., 2016).
T127 1053-1208 Sentence denotes Children with rotavirus enteritis Shortens anti-diarrheal time and total course of time in treating children with rotavirus enteritis (Ma and Wang, 2012).
T128 1209-1307 Sentence denotes Anti-virus Inhibits Avian Influenza Virus H5N1 regulating the gastrointestinal tract (Liu, 2009).
T129 1309-1429 Sentence denotes Influenza Extends relief time of fever symptom, relieves time of muscle aches and relieves time of fatigue (Han, 2016).
T130 1430-1752 Sentence denotes Inhibition effect of vibrio parahaemolyticus, Candida albicans, staphylococcus aureus and diplococcus pneumonia (Zhang, 2013) – Cold Relieves fever, nasal congestion, running nose, spontaneous sweating, headache, cough and spitting, fatigue and weakness, body ache and other cold symptoms (Wu, 2010; Zhao et al., 2017).
T131 1753-1828 Sentence denotes Acute gastro-enteritis Improves total response rate and clinical symptoms.
T132 1829-2088 Sentence denotes LHQWC Anti-virus Inhibits proliferation of influenza virus and regulates immune response to viral infection (Ding et al., 2017; Yao et al., 2020).Inhibits SARS-CoV-2 replication, affects virus morphology and exerts anti-inflammatory activity in vitro (Li R.
T133 2089-2106 Sentence denotes F. et al., 2020).
T134 2108-2602 Sentence denotes COVID-19 Improves the fever, weakness, cough, short breath, chest distress, anorexia and other clinical symptoms of COVID-19, reduces the ratio of common to severe (Cheng et al., 2020; Hu et al., 2020; Lyu et al., 2020).Lianhua Qingwen granule combined with Abidole can effectively relieve clinical symptoms of mild COVID-19 patients, regulate expression of related inflammatory factors, improve the curative effect and reduce the rate of severe illness (Liu et al., 2020; Yu P. et al., 2020).
T135 2603-2743 Sentence denotes Anti-acute lung injury Inhibits expression and secretion level of MCP-1, reduces infiltration of mononuclear macrophages (Li et al., 2019).
T136 2744-2892 Sentence denotes Reduces LDH and MDA level, increases content of GSH-Px, and relieves the exudation of inflammatory cells in the alveolar cavity (Ping et al., 2016).
T137 2893-2972 Sentence denotes Downregulates expression of IKK/IκB/NF-κB signaling pathway (Cui et al., 2016).
T138 2973-3147 Sentence denotes Reduces protein expression and mRNA expression of inflammatory cytokines in lung tissues through reducing content of inflammatory cytokines in mice blood (Tang et al., 2015).
T139 3149-3331 Sentence denotes H1N1 Improves cough, sore throat, body ache and other symptoms of the patients infected with H1N1 virus, and reduces the duration of fever (Duan et al., 2011; Zhao P. et al., 2014).
T140 3332-3484 Sentence denotes Influenza LHQWC has better total response rate, symptom improvement rate and body temperature recovery rate than the control group (Wang et al., 2019).
T141 3485-3650 Sentence denotes URI Improves the patients’ nasal congestion, fever, headache, sore throat, weakness, aches in the limbs, intolerance of cold and other clinical symptoms (Li, 2019).
T142 3651-3800 Sentence denotes Chronic obstructive pulmonary Improves the condition of the patients with AECOPD, and reduces release of inflammatory mediators (Dong et al., 2014).
T143 3801-3951 Sentence denotes JHQGG Anti-virus Decreases average level of CRP and IFN-γ in serum of the influenza patients, and decreases inflammatory response (Qi et al., 2016).
T144 3953-4039 Sentence denotes COVID-19 Alleviates symptoms of fever, cough, fatigue and sputum (Duan et al., 2020).
T145 4040-4095 Sentence denotes H1N1 Shortens antipyretic time (Wang C. et al., 2011).
T146 4096-4214 Sentence denotes Influenza Reduces the serum levels of cytokines and improve their immune function (Li et al., 2013; Qi et al., 2016).
T147 4215-4481 Sentence denotes SFJDC Anti-virus Improves mice pneumonia symptoms caused by influenza virus, reduce lung index of the mice infected with H1N1, and significantly reduces mortality rate of the infected animals (Liu et al., 2010; Lv et al., 2013; Qiu et al., 2014; Bao et al., 2019).
T148 4483-4552 Sentence denotes Acute URI + fever Improves respiratory symptoms (Wang and Qiu, 2018)
T149 4553-4721 Sentence denotes Anti-inflammation Reduces the WBC count, and reduces the serum transcription factor NF-κB, chemokine MCP-1, inflammatory mediator BK and COX-2 level (Ma et al., 2018).
T150 4723-4865 Sentence denotes CAP Shortens recover time of multiple symptoms and signs such as fever, reduces levels of PCT, CRP and WBC and other indicators (Wang, 2016).
T151 4866-5097 Sentence denotes Immune-regulation Reduces levels of B lymphocytes, CD8+ proportion, IL-1α, IL-1β, IL-2, IgM, IgG, etc., reduces quality of thymus, spleen and lung of pneumonia mice, and increase CD4+/CD8+ and NK cell proportion (Ma et al., 2019).
T152 5099-5156 Sentence denotes AECOPD Reduces levels of IL-8, TNF-α, CRP and PCT (Yu H.
T153 5157-5225 Sentence denotes X. et al., 2020) and increases arterial blood gas PaO2 (Wang, 2015).
T154 5226-5362 Sentence denotes Anti-acute lung injury Inhibition of the MAPK/NF-κB signaling pathway, and down-regulation of NF-κB mRNA expression (Tao et al., 2014).
T155 5363-5444 Sentence denotes The action might be closely related with ERK signaling pathway (Li et al., 2017).
T156 5446-5626 Sentence denotes Bacterial acute bronchitis and Pneumonia Shortens recovery time of body temperature, duration of cough and the course of treatment, and increases oxygen index (Wang et al., 2014).
T157 5627-5779 Sentence denotes TRQI Anti-virus Inhibition of intracellular proliferation and enhancement of body immunity of mice infected with influenza virus (Zheng and Gu, 2009).
T158 5780-5928 Sentence denotes Destroys MRSA biofilm, and induces its death, and when in combined use with vancomycin or linezolid below the MIC concentration (Yang et al., 2018).
T159 5930-6054 Sentence denotes Viral pneumonia A systematic review: TRQI had advantages in response rate of treatment, average length of stay (Pan, 2016).
T160 6055-6124 Sentence denotes Anti-bacteria Destroys the bacterial biofilm (Wang Y. et al., 2011).
T161 6126-6245 Sentence denotes Acute bronchitis Improves response rate, reduce fever, cough, crackles and X-ray shadow absorption (Wang et al., 2016)
T162 6246-6426 Sentence denotes Anti-inflammation Inhibits release of inflammatory factors such as TNF-α, IL-6 and NO, and inhibits airway inflammation caused by LPS through MAPK/NF-B pathway (Liu et al., 2016).
T163 6428-6510 Sentence denotes Acute attack of chronic bronchitis Improves clinical symptoms (Gao et al., 2019).
T164 6511-6639 Sentence denotes Anti-airway mucus hypersecretion Regulates the IL-17 signaling pathway and its downstream protein MUC5AC (Liu W. et al., 2019).
T165 6641-6846 Sentence denotes CAP Improves clinical effect and the symptom of cough with expectoration, shortens the duration of fever and promotes shadow absorption on chest radiography and the hemogram recovery (Jiang et al., 2009).
T166 6847-7003 Sentence denotes Anti-acute lung injury Improves blood flow status of capillaries in the alveolar walls while repressing LPS-induced inflammatory cascade (Li et al., 2005).
T167 7005-7224 Sentence denotes Tuberculosis accompanied by infection A systematic review: TRQI might have the same overall effect with some antibacterial drugs in treating patients with tuberculosis accompanied by lung infection (Lian et al., 2018).
T168 7225-7376 Sentence denotes AECOPD Reduction of the patients’ serum IL-8 and NE level, and improvement of airway inflammation reaction and mucus hypersecretion (Li et al., 2010).
T169 7377-7528 Sentence denotes A systematic review: improves clinical effect and lung function of AECOPD patients, reduces pCO2, and shortens the length of stay (Zhong et al., 2010).
T170 7529-7610 Sentence denotes XYPI Anti-virus Inhibits proliferation of human rhinovirus in mice (Liu, 2015).
T171 7612-7716 Sentence denotes Viral pneumonia Increases the cure rate, and improve the symptoms and signs (Li, 2015; Qi et al., 2018)
T172 7717-8018 Sentence denotes Anti-acute lung injury Inhibits release of proinflammatory cytokines such as IL-10, IL4, etc., and could promote the proinflammatory cytokines/anti-inflammatory cytokines to tend to be balanced, and inhibit excess anti-inflammatory responses during the course of acute lung injury (Nie et al., 2012).
T173 8020-8279 Sentence denotes Severe pneumonia Shortens the course of disease, improves the treatment efficiency, reduces incidence rate of antibiotic resistance, reduces occurrence of double infection, further improves the prognosis and reduces the mortality rate (Zhang and Wang, 2015).
T174 8280-8511 Sentence denotes Reduces leukocytes, improve oxygen index, lower CPIS score, promotes absorption of pulmonary inflammation, shortens the duration of mechanical ventilation and length of stay in ICU, and improves clinical effect (Yang et al., 2014).
T175 8512-8687 Sentence denotes Inhibition effect of staphylococcus aureus and pneumonia streptococcus (Yu et al., 2009) – Upper respiratory infection Improves symptoms of the patients (Liu and Li, 2015).
T176 8688-8842 Sentence denotes XBJI Anti-inflammation Downregulates expression of inflammatory cytokines stimulated by Pam3CSK4 and activating MAPK, PI3K/Akt and other pathways (Li T.
T177 8843-8860 Sentence denotes T. et al., 2020).
T178 8861-9062 Sentence denotes Reduces TNF-α, IL-6 and IL-10 level of mice with sepsis, prevents the neutrophils from infiltrating the lung and kidney, inhibit Th1/Th2, Th17 and Tregs balance (Zhang et al., 2006; Chen et al., 2018).
T179 9064-9169 Sentence denotes COVID-19 Improves the inflammatory markers and prognosis of severe COVID-19 patients (Wen et al., 2020).
T180 9170-9306 Sentence denotes SIRS Expression of CD4+, CD4+/CD8+, CD14+/HLA-DR increased, and improves systematic status of the SIRS patients (Zhao W. et al., 2014).
T181 9307-9508 Sentence denotes Severe pneumonia Reduces the level of inflammatory factors, improves the total treatment efficiency (Qi et al., 2011), reduces infectious indicators and the average length of stays (Zhu et al., 2014).
T182 9509-9658 Sentence denotes Anti-acute lung injury Reduces TNF-α level, alleviates the degree of pulmonary tissue edema and inflammatory cell infiltration (Zhang et al., 2014).
T183 9660-9825 Sentence denotes SCAP Improves primary endpoint-pneumonia severity index, reduces mortality rate in 28 days, and shortens the duration of mechanical ventilation (Song et al., 2019).
T184 9826-10028 Sentence denotes Immune-regulation Blocks p-38 MAPK and NF-κB 65 pathways (Liu et al., 2014); reduces IL-1, IL-6 and TNF-α level, improves CD4+/CD8+ T lymphocyte ratio and NK cell relative activity (Teng et al., 2012).
T185 10030-10218 Sentence denotes AECOPD Lowers the inflammatory indicators, improve cough, expectoration, short breath and other clinical symptoms, and shortens their length of stay (Chen et al., 2011; Zhu et al., 2019).
T186 10219-10297 Sentence denotes Anti-oxidation Improves activity of SOD, reduce ROS level (Jin et al., 2018).
T187 10298-10337 Sentence denotes Downregulates MDA (Luo and Zhou, 2017).
T188 10339-10454 Sentence denotes Sepsis Reduces mortality rate of sepsis patients in 28 days, the APACHE-II and body temperature (Li et al., 2018).
T189 10455-10629 Sentence denotes SFI Anti-acute lung injury Increases the wet/dry weight ratio of lung tissues, neutrophil ratio in BALF, protein content, lung tissue MDA and serum NO (Lin and Zhan, 2010).
T190 10630-10691 Sentence denotes Reduces activation of NF-κB of lung tissue (Ai et al., 2006).
T191 10692-10807 Sentence denotes Reduces expression level of p65, P50 mRNA and protein in lung tissues and TNF-α level in serum (Liu et al., 2019a).
T192 10809-10935 Sentence denotes Sepsis Lowers IL-6 level, regulate balance between pro-inflammatory factors and anti-inflammatory factors (Qiu et al., 2012).
T193 10936-11061 Sentence denotes Increases CD4+ and CD8+T cell counts in peripheral blood and upregulated HLA-DR expression in monocytes (Zhang et al., 2017).
T194 11062-11172 Sentence denotes Anti-shock Increases content of ATP and taurine, and reduces content of AMP in the heart (Liu et al., 2019b).
T195 11174-11261 Sentence denotes Severe pneumonia of elderly Decreases level of TNF-α, IL-6 and IL-8 (Lv et al., 2017).
T196 11262-11381 Sentence denotes Acute lung injury Improves respiratory rate, oxygen index, and lowers the ICAM-1, ET-1 and NO level (Ma et al., 2019).
T197 11382-11502 Sentence denotes Respiratory failure Improves serum prealbumin, oxygen index, shortens the duration of mechanical ventilation (Li, 2013)
T198 11503-11641 Sentence denotes SMI Improve pulmonary function Raises NO level, dropping oxygen free radical levels and decreases lipid peroxidation (Lin et al., 2007).
T199 11642-11725 Sentence denotes Lowers expression of NF-κB and activity of iNOS in lung tissues (Liu et al., 2009).
T200 11727-11852 Sentence denotes COPD Improves pulmonary function index, blood gas index, IgG index and disappearance time of lung rale (Huang et al., 2019).
T201 11853-11932 Sentence denotes Anti-inflammation Inhibits expression of ICAM-1 and VCAM-1 (Liu et al., 2015).
T202 11933-12079 Sentence denotes Inhibits generation of inflammatory cytokines of ischemia-reperfusion rats, lowers expression level of TNF-α, IL-6, IL-8, etc. (Wang et al., 2015)
T203 12080-12142 Sentence denotes Immune-regulation Inhibits monocyte MCP-1 (Liu et al., 2015).
T204 12143-12286 Sentence denotes Increases the content of serum immunoglobulin IgG and the number of T cells, enhances the phagocytic function of macrophages (Du et al., 2001).
T205 12288-12485 Sentence denotes Prevent inflammatory response Improves microcirculation, protect the organ functions, and prevents further occurrence and development of systemic inflammatory response syndrome (Guo et al., 2004).
T206 12486-12619 Sentence denotes Improve pulmonary function Raises NO level, dropping oxygen free radical levels and decreases lipid peroxidation (Lin et al., 2007).
T207 12620-12703 Sentence denotes Lowers expression of NF-κB and activity of iNOS in lung tissues (Liu et al., 2009).
T208 12704-12870 Sentence denotes AGNHP Anti-inflammation Inhibits release of superoxide radical; reverses changes in cortical monoamine neurotransmitters (Zhang F. et al., 2010; Zhu and Sun, 2014).
T209 12871-12954 Sentence denotes Lowers serum LPS level and lung myeloperoxidase (MPO) content (Zhang et al., 2009).
T210 12955-13038 Sentence denotes Lowers total LDH activity, and changes percentage of isomerase (Tang et al., 2005).
T211 13040-13285 Sentence denotes Hyperpyrexia, coma caused by severe infectious diseases Promotes consciousness, improves the neurologic function (Feng and Yang, 2015), shortens average defervescence time (Long and Wu, 2014) and moderates effect on Th1/Th2 (Ma and Zhou, 2015).
T212 13286-13450 Sentence denotes Viral encephalitis Reduces body temperature, avoids convulsion, promotes consciousness, and alleviates cerebral edema and brain cell damage (Zhang and Dong, 2014).
T213 13451-13704 Sentence denotes Neuroprotective effect Regulates Th17/Treg balance, inhibits chronic inflammation, reduces plaque collagen fibers, and reduces inflammatory cells infiltration (Fan et al., 2020) Pneumonia Reduces PCT and improves immune function (Zhuo and Wen, 2017).
T214 13705-13807 Sentence denotes Antipyretic and analgesic – ACI intracerebral hemorrhage Neuroprotective effect (Han et al., 2019).
T215 13808-14056 Sentence denotes Research by Zhonghua Liu et al. (Liu, 2009) revealed that HXZQC inhibited the lung index of mice infected with avian influenza virus (AIV) H5N1, reduced the development of lung disease, and enhanced the antiviral capacity of mice infected with AIV.
T216 14057-14190 Sentence denotes The death rate of the infected mice was reduced through regulation of the gastrointestinal tract and strengthening of the stomach Qi.
T217 14191-14351 Sentence denotes Hongkun Zhang (Zhang, 2013) found that HXZQC inhibited growth of Vibrio parahaemolyticus, Candida albicans, Staphylococcus aureus, and Streptococcus pneumoniae.
T218 14352-14633 Sentence denotes Research by Wang et al. (2012) found that HXZQC inhibited lipopolysaccharide (LPS)-stimulated expression of proinflammatory cytokines by macrophages and inhibited epithelial barrier disorder induced by interferon-γ (IFN-γ), regulating immunity and improving gastroenteric function.
T219 14634-14896 Sentence denotes Research by Chunyuan Li et al. (Li et al., 2017) showed that HXZQC significantly improved the thymus coefficient, spleen coefficient and immunoglobulin G (IgG) levels of mice with dampness obstructing spleen-stomach, and enhanced the immune function of the mice.
T220 14897-15226 Sentence denotes Studies by Yinghui He et al. (He et al., 2006) and Shaobo Zong et al. (Zong et al., 2015) discovered that HXZQC had therapeutic effects in mice with Bacillus dysenteriae and Salmonella typhimurium-induced diarrhea (BSD mice), mice with bacterial enteritis, and model rats with diarrhea-predominant irritable bowel syndrome (IBS).
T221 15227-15485 Sentence denotes Clinical symptoms were significantly improved, which might be due to effects on the balance of CD4+ and CD8+ T lymphocytes, and reduction of interleukin-2 (IL-2), interleukin-10 (IL-10), interleukin-1β (IL-1β), and tumor necrosis factor alpha (TNF-α) levels.
T222 15486-15645 Sentence denotes The results suggested that HXZQC, via immune-regulation and anti-inflammatory activity, could have therapeutic effects against many gastrointestinal disorders.
T223 15646-15858 Sentence denotes Research by Hefei Huang et al. (Huang et al., 2016) showed that HXZQC extracts had a positive regulatory effect on intestinal dysfunction, and had therapeutic efficacy in model rats with diarrhea-predominant IBS.
T224 15859-16014 Sentence denotes Efficacy was mediated by improving serum NO levels and reducing the concentrations of 5-hydroxytryptamine (5-HT), plasma motilin, and colonic somatostatin.