LitCovid-sentences  

PMC:7396557 / 11028-32223 JSONTXT 12 Projects

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Id Subject Object Predicate Lexical cue
T98 0-57 Sentence denotes Relevant Information on the Clinical Application of HXZQC
T99 59-91 Sentence denotes Recommended Therapeutic Regimens
T100 92-217 Sentence denotes HXZQC has been recommended in 20 therapeutic regimens for COVID-19 in China (see detailed information in Tables 1 and 2 ).
T101 218-289 Sentence denotes Table 2 List of recommended CPMs in therapeutic regimens for COVID-19.
T102 290-367 Sentence denotes Drug name Therapeutic regimens of COVID-19 Number of “therapeutic regimens”
T103 368-401 Sentence denotes AGNHP 2-13, 15‑19, 21‑23, 25 21
T104 402-441 Sentence denotes HXZQC 1, 4-8, 10‑16, 18, 19, 21‑25 20
T105 442-483 Sentence denotes XBJI 1-4, 6, 7, 10‑13, 15, 16, 17‑25 20
T106 484-526 Sentence denotes LHQWC 1, 2, 4-7, 11‑16, 18, 19, 21‑25 19
T107 527-564 Sentence denotes SFI 1-4, 6, 10‑13, 15, 16, 18‑25 19
T108 565-606 Sentence denotes SMI 1, 3, 6, 7, 10‑13, 15, 16, 18‑25 18
T109 607-650 Sentence denotes SFJDC 1, 4‑7, 11‑13, 16, 18, 19, 21‑24 15
T110 651-689 Sentence denotes XYPI 1, 3, 6, 7, 10‑13, 15, 20‑25 15
T111 690-738 Sentence denotes JHQGG 1, 2, 4‑7, 11, 12, 18, 21, 22, 24, 25 13
T112 739-781 Sentence denotes TRQI 1-3, 6, 7, 11‑13, 16, 19, 21, 22 12
T113 783-803 Sentence denotes Ingredients of HXZQC
T114 804-1369 Sentence denotes Pogostemon cablin (Blanco) Benth. (Guanghuoxiang), Atractylodes macrocephala Koidz. (Baizhu), Magnolia officinalis Rehder & E.H.Wilson (Houpo), Pinellia ternata (Thunb.) Makino (Banxia), Perilla frutescens (L.) Britton (Zisu), Angelica dahurica (Hoffm.) Benth. & Hook.f. ex Franch. & Sav. (Baizhi), Citrus × aurantium L. (Chenpi), Poria cocos (Schw.) Wolf (Fuling), Platycodon grandiflorus (Jacq.) A.DC. (Jiegeng), Glycyrrhiza uralensis Fisch. ex DC. (Gancao), Ziziphus jujuba Mill. (Dazao), Areca catechu L. (Binglang), and Zingiber officinale Roscoe (Shengjiang).
T115 1370-1438 Sentence denotes Basic information on HXZQC is provided in the Supplementary Table .
T116 1440-1492 Sentence denotes Indications for the Treatment of COVID-19 With HXZQC
T117 1493-1646 Sentence denotes HXZQC is used for cold outside and inside damp indications during the clinical observation period of COVID-19 and early stage of the disease (mild case).
T118 1647-1771 Sentence denotes The indicative symptoms include weakness, headache and dizziness, abdominal fullness and distention, vomiting, and diarrhea.
T119 1773-1818 Sentence denotes Progress of Pharmacological Research on HXZQC
T120 1819-2014 Sentence denotes Modern pharmacological studies have found that HXZQC has antiviral, anti-inflammatory, and immune regulatory activities, improves gastrointestinal discomfort and other properties (see Table 3 ).
T121 2015-2117 Sentence denotes Table 3 Pharmacological functions and clinical research on top 10 CPMs for the treatment of COVID-19.
T122 2118-2206 Sentence denotes Drug name Pharmacological action Mechanism Clinical application Therapeutic efficacy
T123 2207-2405 Sentence denotes HXZQC Regulate the immunity and improve the gastroenteric function Inhibits LPS and epithelial barrier disorder, stipulate expression of proinflammatory cytokine of macrophage (Wang et al., 2012).
T124 2406-2513 Sentence denotes Improve thymus coefficient, spleen coefficient, immunoglobulin G (IgG) level of the mice (Li et al., 2017).
T125 2514-2667 Sentence denotes Regulates effect of the balance of CD4+ and CD8+ T lymphocytes, and reduction of IL-2, IL-10, IL-1β and TNF-α level (He et al., 2006; Zong et al., 2015).
T126 2668-2824 Sentence denotes Improves serum NO level of rats, reduces concentration of 5-HT, and downregulates the level of plasma motilin and colonic somatostatin (Huang et al., 2016).
T127 2826-2981 Sentence denotes Children with rotavirus enteritis Shortens anti-diarrheal time and total course of time in treating children with rotavirus enteritis (Ma and Wang, 2012).
T128 2982-3080 Sentence denotes Anti-virus Inhibits Avian Influenza Virus H5N1 regulating the gastrointestinal tract (Liu, 2009).
T129 3082-3202 Sentence denotes Influenza Extends relief time of fever symptom, relieves time of muscle aches and relieves time of fatigue (Han, 2016).
T130 3203-3525 Sentence denotes Inhibition effect of vibrio parahaemolyticus, Candida albicans, staphylococcus aureus and diplococcus pneumonia (Zhang, 2013) – Cold Relieves fever, nasal congestion, running nose, spontaneous sweating, headache, cough and spitting, fatigue and weakness, body ache and other cold symptoms (Wu, 2010; Zhao et al., 2017).
T131 3526-3601 Sentence denotes Acute gastro-enteritis Improves total response rate and clinical symptoms.
T132 3602-3861 Sentence denotes LHQWC Anti-virus Inhibits proliferation of influenza virus and regulates immune response to viral infection (Ding et al., 2017; Yao et al., 2020).Inhibits SARS-CoV-2 replication, affects virus morphology and exerts anti-inflammatory activity in vitro (Li R.
T133 3862-3879 Sentence denotes F. et al., 2020).
T134 3881-4375 Sentence denotes COVID-19 Improves the fever, weakness, cough, short breath, chest distress, anorexia and other clinical symptoms of COVID-19, reduces the ratio of common to severe (Cheng et al., 2020; Hu et al., 2020; Lyu et al., 2020).Lianhua Qingwen granule combined with Abidole can effectively relieve clinical symptoms of mild COVID-19 patients, regulate expression of related inflammatory factors, improve the curative effect and reduce the rate of severe illness (Liu et al., 2020; Yu P. et al., 2020).
T135 4376-4516 Sentence denotes Anti-acute lung injury Inhibits expression and secretion level of MCP-1, reduces infiltration of mononuclear macrophages (Li et al., 2019).
T136 4517-4665 Sentence denotes Reduces LDH and MDA level, increases content of GSH-Px, and relieves the exudation of inflammatory cells in the alveolar cavity (Ping et al., 2016).
T137 4666-4745 Sentence denotes Downregulates expression of IKK/IκB/NF-κB signaling pathway (Cui et al., 2016).
T138 4746-4920 Sentence denotes Reduces protein expression and mRNA expression of inflammatory cytokines in lung tissues through reducing content of inflammatory cytokines in mice blood (Tang et al., 2015).
T139 4922-5104 Sentence denotes H1N1 Improves cough, sore throat, body ache and other symptoms of the patients infected with H1N1 virus, and reduces the duration of fever (Duan et al., 2011; Zhao P. et al., 2014).
T140 5105-5257 Sentence denotes Influenza LHQWC has better total response rate, symptom improvement rate and body temperature recovery rate than the control group (Wang et al., 2019).
T141 5258-5423 Sentence denotes URI Improves the patients’ nasal congestion, fever, headache, sore throat, weakness, aches in the limbs, intolerance of cold and other clinical symptoms (Li, 2019).
T142 5424-5573 Sentence denotes Chronic obstructive pulmonary Improves the condition of the patients with AECOPD, and reduces release of inflammatory mediators (Dong et al., 2014).
T143 5574-5724 Sentence denotes JHQGG Anti-virus Decreases average level of CRP and IFN-γ in serum of the influenza patients, and decreases inflammatory response (Qi et al., 2016).
T144 5726-5812 Sentence denotes COVID-19 Alleviates symptoms of fever, cough, fatigue and sputum (Duan et al., 2020).
T145 5813-5868 Sentence denotes H1N1 Shortens antipyretic time (Wang C. et al., 2011).
T146 5869-5987 Sentence denotes Influenza Reduces the serum levels of cytokines and improve their immune function (Li et al., 2013; Qi et al., 2016).
T147 5988-6254 Sentence denotes SFJDC Anti-virus Improves mice pneumonia symptoms caused by influenza virus, reduce lung index of the mice infected with H1N1, and significantly reduces mortality rate of the infected animals (Liu et al., 2010; Lv et al., 2013; Qiu et al., 2014; Bao et al., 2019).
T148 6256-6325 Sentence denotes Acute URI + fever Improves respiratory symptoms (Wang and Qiu, 2018)
T149 6326-6494 Sentence denotes Anti-inflammation Reduces the WBC count, and reduces the serum transcription factor NF-κB, chemokine MCP-1, inflammatory mediator BK and COX-2 level (Ma et al., 2018).
T150 6496-6638 Sentence denotes CAP Shortens recover time of multiple symptoms and signs such as fever, reduces levels of PCT, CRP and WBC and other indicators (Wang, 2016).
T151 6639-6870 Sentence denotes Immune-regulation Reduces levels of B lymphocytes, CD8+ proportion, IL-1α, IL-1β, IL-2, IgM, IgG, etc., reduces quality of thymus, spleen and lung of pneumonia mice, and increase CD4+/CD8+ and NK cell proportion (Ma et al., 2019).
T152 6872-6929 Sentence denotes AECOPD Reduces levels of IL-8, TNF-α, CRP and PCT (Yu H.
T153 6930-6998 Sentence denotes X. et al., 2020) and increases arterial blood gas PaO2 (Wang, 2015).
T154 6999-7135 Sentence denotes Anti-acute lung injury Inhibition of the MAPK/NF-κB signaling pathway, and down-regulation of NF-κB mRNA expression (Tao et al., 2014).
T155 7136-7217 Sentence denotes The action might be closely related with ERK signaling pathway (Li et al., 2017).
T156 7219-7399 Sentence denotes Bacterial acute bronchitis and Pneumonia Shortens recovery time of body temperature, duration of cough and the course of treatment, and increases oxygen index (Wang et al., 2014).
T157 7400-7552 Sentence denotes TRQI Anti-virus Inhibition of intracellular proliferation and enhancement of body immunity of mice infected with influenza virus (Zheng and Gu, 2009).
T158 7553-7701 Sentence denotes Destroys MRSA biofilm, and induces its death, and when in combined use with vancomycin or linezolid below the MIC concentration (Yang et al., 2018).
T159 7703-7827 Sentence denotes Viral pneumonia A systematic review: TRQI had advantages in response rate of treatment, average length of stay (Pan, 2016).
T160 7828-7897 Sentence denotes Anti-bacteria Destroys the bacterial biofilm (Wang Y. et al., 2011).
T161 7899-8018 Sentence denotes Acute bronchitis Improves response rate, reduce fever, cough, crackles and X-ray shadow absorption (Wang et al., 2016)
T162 8019-8199 Sentence denotes Anti-inflammation Inhibits release of inflammatory factors such as TNF-α, IL-6 and NO, and inhibits airway inflammation caused by LPS through MAPK/NF-B pathway (Liu et al., 2016).
T163 8201-8283 Sentence denotes Acute attack of chronic bronchitis Improves clinical symptoms (Gao et al., 2019).
T164 8284-8412 Sentence denotes Anti-airway mucus hypersecretion Regulates the IL-17 signaling pathway and its downstream protein MUC5AC (Liu W. et al., 2019).
T165 8414-8619 Sentence denotes CAP Improves clinical effect and the symptom of cough with expectoration, shortens the duration of fever and promotes shadow absorption on chest radiography and the hemogram recovery (Jiang et al., 2009).
T166 8620-8776 Sentence denotes Anti-acute lung injury Improves blood flow status of capillaries in the alveolar walls while repressing LPS-induced inflammatory cascade (Li et al., 2005).
T167 8778-8997 Sentence denotes Tuberculosis accompanied by infection A systematic review: TRQI might have the same overall effect with some antibacterial drugs in treating patients with tuberculosis accompanied by lung infection (Lian et al., 2018).
T168 8998-9149 Sentence denotes AECOPD Reduction of the patients’ serum IL-8 and NE level, and improvement of airway inflammation reaction and mucus hypersecretion (Li et al., 2010).
T169 9150-9301 Sentence denotes A systematic review: improves clinical effect and lung function of AECOPD patients, reduces pCO2, and shortens the length of stay (Zhong et al., 2010).
T170 9302-9383 Sentence denotes XYPI Anti-virus Inhibits proliferation of human rhinovirus in mice (Liu, 2015).
T171 9385-9489 Sentence denotes Viral pneumonia Increases the cure rate, and improve the symptoms and signs (Li, 2015; Qi et al., 2018)
T172 9490-9791 Sentence denotes Anti-acute lung injury Inhibits release of proinflammatory cytokines such as IL-10, IL4, etc., and could promote the proinflammatory cytokines/anti-inflammatory cytokines to tend to be balanced, and inhibit excess anti-inflammatory responses during the course of acute lung injury (Nie et al., 2012).
T173 9793-10052 Sentence denotes Severe pneumonia Shortens the course of disease, improves the treatment efficiency, reduces incidence rate of antibiotic resistance, reduces occurrence of double infection, further improves the prognosis and reduces the mortality rate (Zhang and Wang, 2015).
T174 10053-10284 Sentence denotes Reduces leukocytes, improve oxygen index, lower CPIS score, promotes absorption of pulmonary inflammation, shortens the duration of mechanical ventilation and length of stay in ICU, and improves clinical effect (Yang et al., 2014).
T175 10285-10460 Sentence denotes Inhibition effect of staphylococcus aureus and pneumonia streptococcus (Yu et al., 2009) – Upper respiratory infection Improves symptoms of the patients (Liu and Li, 2015).
T176 10461-10615 Sentence denotes XBJI Anti-inflammation Downregulates expression of inflammatory cytokines stimulated by Pam3CSK4 and activating MAPK, PI3K/Akt and other pathways (Li T.
T177 10616-10633 Sentence denotes T. et al., 2020).
T178 10634-10835 Sentence denotes Reduces TNF-α, IL-6 and IL-10 level of mice with sepsis, prevents the neutrophils from infiltrating the lung and kidney, inhibit Th1/Th2, Th17 and Tregs balance (Zhang et al., 2006; Chen et al., 2018).
T179 10837-10942 Sentence denotes COVID-19 Improves the inflammatory markers and prognosis of severe COVID-19 patients (Wen et al., 2020).
T180 10943-11079 Sentence denotes SIRS Expression of CD4+, CD4+/CD8+, CD14+/HLA-DR increased, and improves systematic status of the SIRS patients (Zhao W. et al., 2014).
T181 11080-11281 Sentence denotes Severe pneumonia Reduces the level of inflammatory factors, improves the total treatment efficiency (Qi et al., 2011), reduces infectious indicators and the average length of stays (Zhu et al., 2014).
T182 11282-11431 Sentence denotes Anti-acute lung injury Reduces TNF-α level, alleviates the degree of pulmonary tissue edema and inflammatory cell infiltration (Zhang et al., 2014).
T183 11433-11598 Sentence denotes SCAP Improves primary endpoint-pneumonia severity index, reduces mortality rate in 28 days, and shortens the duration of mechanical ventilation (Song et al., 2019).
T184 11599-11801 Sentence denotes Immune-regulation Blocks p-38 MAPK and NF-κB 65 pathways (Liu et al., 2014); reduces IL-1, IL-6 and TNF-α level, improves CD4+/CD8+ T lymphocyte ratio and NK cell relative activity (Teng et al., 2012).
T185 11803-11991 Sentence denotes AECOPD Lowers the inflammatory indicators, improve cough, expectoration, short breath and other clinical symptoms, and shortens their length of stay (Chen et al., 2011; Zhu et al., 2019).
T186 11992-12070 Sentence denotes Anti-oxidation Improves activity of SOD, reduce ROS level (Jin et al., 2018).
T187 12071-12110 Sentence denotes Downregulates MDA (Luo and Zhou, 2017).
T188 12112-12227 Sentence denotes Sepsis Reduces mortality rate of sepsis patients in 28 days, the APACHE-II and body temperature (Li et al., 2018).
T189 12228-12402 Sentence denotes SFI Anti-acute lung injury Increases the wet/dry weight ratio of lung tissues, neutrophil ratio in BALF, protein content, lung tissue MDA and serum NO (Lin and Zhan, 2010).
T190 12403-12464 Sentence denotes Reduces activation of NF-κB of lung tissue (Ai et al., 2006).
T191 12465-12580 Sentence denotes Reduces expression level of p65, P50 mRNA and protein in lung tissues and TNF-α level in serum (Liu et al., 2019a).
T192 12582-12708 Sentence denotes Sepsis Lowers IL-6 level, regulate balance between pro-inflammatory factors and anti-inflammatory factors (Qiu et al., 2012).
T193 12709-12834 Sentence denotes Increases CD4+ and CD8+T cell counts in peripheral blood and upregulated HLA-DR expression in monocytes (Zhang et al., 2017).
T194 12835-12945 Sentence denotes Anti-shock Increases content of ATP and taurine, and reduces content of AMP in the heart (Liu et al., 2019b).
T195 12947-13034 Sentence denotes Severe pneumonia of elderly Decreases level of TNF-α, IL-6 and IL-8 (Lv et al., 2017).
T196 13035-13154 Sentence denotes Acute lung injury Improves respiratory rate, oxygen index, and lowers the ICAM-1, ET-1 and NO level (Ma et al., 2019).
T197 13155-13275 Sentence denotes Respiratory failure Improves serum prealbumin, oxygen index, shortens the duration of mechanical ventilation (Li, 2013)
T198 13276-13414 Sentence denotes SMI Improve pulmonary function Raises NO level, dropping oxygen free radical levels and decreases lipid peroxidation (Lin et al., 2007).
T199 13415-13498 Sentence denotes Lowers expression of NF-κB and activity of iNOS in lung tissues (Liu et al., 2009).
T200 13500-13625 Sentence denotes COPD Improves pulmonary function index, blood gas index, IgG index and disappearance time of lung rale (Huang et al., 2019).
T201 13626-13705 Sentence denotes Anti-inflammation Inhibits expression of ICAM-1 and VCAM-1 (Liu et al., 2015).
T202 13706-13852 Sentence denotes Inhibits generation of inflammatory cytokines of ischemia-reperfusion rats, lowers expression level of TNF-α, IL-6, IL-8, etc. (Wang et al., 2015)
T203 13853-13915 Sentence denotes Immune-regulation Inhibits monocyte MCP-1 (Liu et al., 2015).
T204 13916-14059 Sentence denotes Increases the content of serum immunoglobulin IgG and the number of T cells, enhances the phagocytic function of macrophages (Du et al., 2001).
T205 14061-14258 Sentence denotes Prevent inflammatory response Improves microcirculation, protect the organ functions, and prevents further occurrence and development of systemic inflammatory response syndrome (Guo et al., 2004).
T206 14259-14392 Sentence denotes Improve pulmonary function Raises NO level, dropping oxygen free radical levels and decreases lipid peroxidation (Lin et al., 2007).
T207 14393-14476 Sentence denotes Lowers expression of NF-κB and activity of iNOS in lung tissues (Liu et al., 2009).
T208 14477-14643 Sentence denotes AGNHP Anti-inflammation Inhibits release of superoxide radical; reverses changes in cortical monoamine neurotransmitters (Zhang F. et al., 2010; Zhu and Sun, 2014).
T209 14644-14727 Sentence denotes Lowers serum LPS level and lung myeloperoxidase (MPO) content (Zhang et al., 2009).
T210 14728-14811 Sentence denotes Lowers total LDH activity, and changes percentage of isomerase (Tang et al., 2005).
T211 14813-15058 Sentence denotes Hyperpyrexia, coma caused by severe infectious diseases Promotes consciousness, improves the neurologic function (Feng and Yang, 2015), shortens average defervescence time (Long and Wu, 2014) and moderates effect on Th1/Th2 (Ma and Zhou, 2015).
T212 15059-15223 Sentence denotes Viral encephalitis Reduces body temperature, avoids convulsion, promotes consciousness, and alleviates cerebral edema and brain cell damage (Zhang and Dong, 2014).
T213 15224-15477 Sentence denotes Neuroprotective effect Regulates Th17/Treg balance, inhibits chronic inflammation, reduces plaque collagen fibers, and reduces inflammatory cells infiltration (Fan et al., 2020) Pneumonia Reduces PCT and improves immune function (Zhuo and Wen, 2017).
T214 15478-15580 Sentence denotes Antipyretic and analgesic – ACI intracerebral hemorrhage Neuroprotective effect (Han et al., 2019).
T215 15581-15829 Sentence denotes Research by Zhonghua Liu et al. (Liu, 2009) revealed that HXZQC inhibited the lung index of mice infected with avian influenza virus (AIV) H5N1, reduced the development of lung disease, and enhanced the antiviral capacity of mice infected with AIV.
T216 15830-15963 Sentence denotes The death rate of the infected mice was reduced through regulation of the gastrointestinal tract and strengthening of the stomach Qi.
T217 15964-16124 Sentence denotes Hongkun Zhang (Zhang, 2013) found that HXZQC inhibited growth of Vibrio parahaemolyticus, Candida albicans, Staphylococcus aureus, and Streptococcus pneumoniae.
T218 16125-16406 Sentence denotes Research by Wang et al. (2012) found that HXZQC inhibited lipopolysaccharide (LPS)-stimulated expression of proinflammatory cytokines by macrophages and inhibited epithelial barrier disorder induced by interferon-γ (IFN-γ), regulating immunity and improving gastroenteric function.
T219 16407-16669 Sentence denotes Research by Chunyuan Li et al. (Li et al., 2017) showed that HXZQC significantly improved the thymus coefficient, spleen coefficient and immunoglobulin G (IgG) levels of mice with dampness obstructing spleen-stomach, and enhanced the immune function of the mice.
T220 16670-16999 Sentence denotes Studies by Yinghui He et al. (He et al., 2006) and Shaobo Zong et al. (Zong et al., 2015) discovered that HXZQC had therapeutic effects in mice with Bacillus dysenteriae and Salmonella typhimurium-induced diarrhea (BSD mice), mice with bacterial enteritis, and model rats with diarrhea-predominant irritable bowel syndrome (IBS).
T221 17000-17258 Sentence denotes Clinical symptoms were significantly improved, which might be due to effects on the balance of CD4+ and CD8+ T lymphocytes, and reduction of interleukin-2 (IL-2), interleukin-10 (IL-10), interleukin-1β (IL-1β), and tumor necrosis factor alpha (TNF-α) levels.
T222 17259-17418 Sentence denotes The results suggested that HXZQC, via immune-regulation and anti-inflammatory activity, could have therapeutic effects against many gastrointestinal disorders.
T223 17419-17631 Sentence denotes Research by Hefei Huang et al. (Huang et al., 2016) showed that HXZQC extracts had a positive regulatory effect on intestinal dysfunction, and had therapeutic efficacy in model rats with diarrhea-predominant IBS.
T224 17632-17787 Sentence denotes Efficacy was mediated by improving serum NO levels and reducing the concentrations of 5-hydroxytryptamine (5-HT), plasma motilin, and colonic somatostatin.
T225 17789-17815 Sentence denotes Clinical Research on HXZQC
T226 17816-18028 Sentence denotes Modern clinical studies have shown that HXZQC has therapeutic effects against viral diseases, such as gastrointestinal-type cold, influenza, upper respiratory infection (URI), and viral enteritis (see Table 3 ).
T227 18029-18275 Sentence denotes The Diagnosis and Treatment Scheme of Severe Acute Respiratory Syndrome (SARS) (Version 2004) (Chinese Medical Association and China Association of Chinese Medicine, 2004) recommended that HXZQC could be used for advanced stage pulmonary closure.
T228 18276-18594 Sentence denotes Research by Shuping Ma et al. showed that, compared with the control group (Ribavirin, interferon), HXZQC + Western medicines (Ribavirin, interferon) had a significant effect on antidiarrheal time and shortened the total time course in the treatment of children with rotavirus enteritis (p < 0.05) (Ma and Wang, 2012).
T229 18595-18696 Sentence denotes Xiaoping Han et al. (Han, 2016) randomized 78 influenza patients into control and observation groups.
T230 18697-18858 Sentence denotes Patients in the control group were given oral oseltamivir phosphate, while patients in the observation group received HXZQC in addition to oseltamivir phosphate.
T231 18859-19009 Sentence denotes Compared with those in the control group, patients in the observation group had faster relief of fever symptoms, muscle aches, and fatigue (p < 0.05).
T232 19010-19136 Sentence denotes The total response rate in the observation group was 97.44%, which was higher than the 82.05% of the control group (p < 0.05).
T233 19137-19244 Sentence denotes The results showed that HXZQC enhanced the efficacy of oseltamivir phosphate in the treatment of influenza.
T234 19245-19472 Sentence denotes Xingzhou Wu (Wu, 2010) randomized 90 cold dampness patients into two groups: the treatment group received HXZQP, while the control group received Ribavirin injection + Compound paracetamol and amantadine hydrochloride capsules.
T235 19473-19580 Sentence denotes The total response rate in the treatment group was 88.9% compared to 77.1% in the control group (p < 0.05).
T236 19581-19843 Sentence denotes Patients in the treatment group exhibited greater improvements in aversion to cold, fever, nasal congestion, running nose, spontaneous sweating, headache, cough and spitting, fatigue and weakness, body ache, and other cold symptoms compared to the control group.
T237 19844-19977 Sentence denotes Hongjie Zhao et al. studied the efficacy and safety of HXZQC in the treatment of gastrointestinal-type cold by systematic evaluation.
T238 19978-20222 Sentence denotes A total of 680 patients in eight randomized controlled trials (RCTs) were included in the research, and the results showed that the group receiving HXZQC had a significantly better clinical response than the group using Western medicines alone.
T239 20223-20388 Sentence denotes The effects of HXZQC were superior to Western medicines in improving single symptoms (such as aversion to cold, fever, bowel sound and diarrhea) (Zhao et al., 2017).
T240 20389-20510 Sentence denotes Dandan Yu et al. conducted a meta-analysis of 44 studies, including a total of 4,153 patients with acute gastroenteritis.
T241 20511-20731 Sentence denotes The results showed that treatment with HXZQP + conventional therapy or norfloxacin tablets was superior to a single Western medicine in terms of total response rate and improvement of clinical symptoms (Yu et al., 2019).
T242 20733-20758 Sentence denotes Usage and Dosage of HXZQC
T243 20759-20807 Sentence denotes Oral administration, four capsules, twice a day.
T244 20809-20835 Sentence denotes Adverse Reactions of HXZQC
T245 20836-20993 Sentence denotes Potential drug eruption, purpura, shock, asthma, intestinal obstruction, upper gastrointestinal hemorrhage, hypoglycemia of childhood, infantile convulsions.
T246 20995-21012 Sentence denotes HXZQC Precautions
T247 21013-21109 Sentence denotes 1) Nourishing traditional Chinese medicines should not be taken during the period of medication.
T248 21110-21195 Sentence denotes 2) It is advisable that patients are on a light diet during the period of medication.