PMC:7388103 / 2632-4583 JSONTXT 11 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T23 0-16 Sentence denotes Case Description
T24 17-117 Sentence denotes A 63-year-old male without comorbidities presented with 1 week of dry cough, myalgias, and diarrhea.
T25 118-212 Sentence denotes On examination, he was afebrile but appeared to be in distress, saturating at 89% on room air.
T26 213-265 Sentence denotes Chest X-ray showed bilateral interstitial opacities.
T27 266-389 Sentence denotes Initial laboratory tests revealed an elevated C-reactive protein of 24.49 mg/dL and a high interleukin-6 level of 58 pg/mL.
T28 390-496 Sentence denotes Fibrinogen and D-dimer were also elevated to 708 mg/dL and 1.44 fibrinogen equivalent units, respectively.
T29 497-567 Sentence denotes The platelet count and liver function tests were within normal limits.
T30 568-665 Sentence denotes He was diagnosed with COVID-19 by nasopharyngeal reverse-transcriptase–polymerase chain reaction.
T31 666-730 Sentence denotes Low-molecular-weight heparin was started for thromboprophylaxis.
T32 731-853 Sentence denotes On day 2 of admission, he developed progressive worsening of dyspnea and was transferred to the intensive care unit (ICU).
T33 854-914 Sentence denotes On day 7, his right lower extremity was noted to be swollen.
T34 915-1003 Sentence denotes Ultrasound duplex revealed a nonocclusive thrombus within the right common femoral vein.
T35 1004-1182 Sentence denotes He was started on therapeutic anticoagulation for deep vein thrombosis with enoxaparin, which was switched to unfractionated heparin (UFH) later, due to worsening renal function.
T36 1183-1283 Sentence denotes On the same day, due to worsening respiratory failure, he was intubated and mechanically ventilated.
T37 1284-1382 Sentence denotes Between days 11 and 12 of hospitalization, platelet count dropped from 304 000 to 96 000 cells/µL.
T38 1383-1446 Sentence denotes He had a high pretest probability for HIT with a 4T score of 6.
T39 1447-1612 Sentence denotes HIT antibody testing (anti-PF4/heparin antibody, by enzyme-linked immunosorbent assay) was sent, which returned positive with an optical density (OD) of 1.243 units.
T40 1613-1674 Sentence denotes Heparin drip was discontinued and was switched to argatroban.
T41 1675-1738 Sentence denotes Unfortunately, he died a day later, following a cardiac arrest.
T42 1739-1914 Sentence denotes Serotonin release assay (SRA) eventually returned positive, with 49% serotonin release at low UFH dose (0.1 IU/mL) with a reduction to 0% release at high UFH dose (100 IU/mL).
T43 1915-1951 Sentence denotes This confirmed the diagnosis of HIT.