LitCovid-sentences  

PMC:7386875 / 7288-9290 JSONTXT 10 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T32 0-9 Sentence denotes Figure 1.
T33 11-171 Sentence denotes Proposed mechanisms of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission, and coronavirus disease 2019 (COVID-19)-associated thrombosis.
T34 172-327 Sentence denotes SARS-CoV-2 gains entry to host lung epithelial cells by the binding of the transmembrane spike (S) glycoprotein to ACE-2 (angiotensin-converting enzyme 2).
T35 328-405 Sentence denotes The S1 subunit of the S protein binds to ACE-2 and mediates viral attachment.
T36 406-562 Sentence denotes Proteolytic cleavage of the S protein at the S1/2 junction by the proteases, furin, and TMPRSS-2 (transmembrane protease serine 2), facilitates viral entry.
T37 563-627 Sentence denotes SARS-CoV-2 can also directly invade endothelial expressed ACE-2.
T38 628-804 Sentence denotes Infected cells undergo pyroptosis leading to the release of danger-associated molecular patterns (DAMPs) and triggering the release of proinflammatory cytokines and chemokines.
T39 805-1073 Sentence denotes The activated endothelium upregulates the expression of VWF (von Willebrand factor) and adhesion molecules including ICAM (intercellular adhesion molecule)-1, αvβ3, P-selectin and E-selectin leading to recruitment of platelets and leukocytes and complement activation.
T40 1074-1182 Sentence denotes Neutrophils release neutrophil extracellular traps (NETS), causing direct activation of the contact pathway.
T41 1183-1597 Sentence denotes Complement activation potentiates these mechanisms by increasing endothelial and monocyte tissue factor (TF), further platelet activation and amplifies endothelial inflammation, which increases production of proinflammatory cytokines from the endothelium including IL (interleukin)-1, IL-8, RANTES (regulated on activation, normal T-cell expressed and secreted), IL-6, and MCP (monocyte chemoattractant protein)-1.
T42 1598-1710 Sentence denotes The hypoxic environment can induce HIFs (hypoxia-inducible factors) which upregulates endothelial TF expression.
T43 1711-1817 Sentence denotes These mechanisms ultimately lead to the unchecked generation of thrombin, resulting in thrombus formation.
T44 1818-2002 Sentence denotes The fibrin degradation product, D-dimer, which is a marker of coagulation activation, appears to be a strong prognostic marker associated with high mortality in patients with COVID-19.