LitCovid-sentences  

PMC:7386875 / 55644-57480 JSONTXT 8 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T190 0-133 Sentence denotes The emergence of the SARS-CoV-2 virus and the ensuing global pandemic has presented unprecedented healthcare and economic challenges.
T191 134-330 Sentence denotes A key clinical feature of severe COVID-19 seems to be a highly prothrombotic state, which is linked to excess rates of arterial, venous and microvascular thrombosis, and adverse clinical outcomes.
T192 331-620 Sentence denotes Emerging evidence suggests that SARS-CoV-2 can infect endothelial cells with the associated immune response and ensuing activation of inflammatory pathways resulting in dysregulation of the endothelium, leukocyte activation, NET generation, complement deposition, and platelet consumption.
T193 621-759 Sentence denotes These pathways can conspire to unleash a prothrombotic state (immunothrombosis), which may result in significant thrombotic complications.
T194 760-1019 Sentence denotes Accordingly, there remains much interest, and an urgent clinical need, to precisely delineate the mechanisms by which SARS-CoV-2 infection causes thrombotic complications in the hope that new insights into this process will yield novel therapeutic approaches.
T195 1020-1113 Sentence denotes This is especially pressing in the absence of an effective therapy or vaccine for SARS-CoV-2.
T196 1114-1396 Sentence denotes Thus, in the context of COVID-19 the intersection of innate and adaptive immunity, inflammation, and thrombosis has been thrust into the global spotlight, and the challenge is now to urgently find therapeutic concepts to disrupt this unholy trinity in the face of a global pandemic.
T197 1397-1614 Sentence denotes The growing awareness and understanding of thrombotic complications in patients with SARS-CoV-2 infection will contribute to a more rigorous diagnostic approach resulting in the earlier detection of thrombotic events.
T198 1615-1836 Sentence denotes Importantly, the shift towards the early institution of antithrombotic therapy for the prevention and treatment of COVID-19-associated thrombosis will hopefully translate into improved outcomes for patients with COVID-19.