PMC:7386875 / 18272-19343 JSON TXT 11 Projects

Annnotations TAB TSV DIC JSON TextAE

Id	Subject	Object	Predicate	Lexical cue
T77	0-356	Sentence	denotes	The primary site of human infection with SARS-CoV-2 is the lung, where S1 attaches with high affinity to ACE-2 expressed on lung alveolar type II epithelial cells (Figure 1).1,2,5 The replication and release of virus from infected cells results in pyroptosis, a highly inflammatory form of cell death that is a common feature among many cytopathic viruses.
T78	357-1071	Sentence	denotes	PRR (Pattern recognition receptors), such as TLR (Toll-like receptors), subsequently detect the release of pathogen-associated molecular patterns, and intracellular danger-associated molecular patterns, such as ATP and DNA, which evokes an intense inflammatory reaction and triggers the release of proinflammatory chemokines and cytokines from neighboring cells (Figure 1).46 Strikingly, SARS-CoV-2 has been found to contain multiple single-stranded RNA fragments that can be recognized by TLR-7 and TLR-8, similar in numbers to MERS-CoV but more than SARS-CoV.47 The recognition of SARS-CoV-2 by these receptors may contribute to innate immune hyperactivation and the cytokine storm often seen in severe COVID-19.