LitCovid-sentences  

PMC:7386785 / 24105-27138 JSONTXT 9 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T268 0-48 Sentence denotes Criteria for considering studies for this review
T269 50-66 Sentence denotes Types of studies
T270 67-295 Sentence denotes We kept the eligibility criteria purposely broad to include all patient groups and all variations of a test at this initial stage of reviewing the evidence (that is, if the patient population was unclear, we included the study).
T271 296-424 Sentence denotes We included studies of all designs that produce estimates of test accuracy or provide data from which estimates can be computed.
T272 425-644 Sentence denotes We included both single‐gate (studies that recruit from a patient pathway before disease status has been ascertained) and multi‐gate (where people with and without the target condition are recruited separately) designs.
T273 645-747 Sentence denotes This means that we included studies that were cross‐sectional or diagnostic case‐control type studies.
T274 748-905 Sentence denotes When interpreting the results, we made sure that the limitations of different study designs were carefully considered, using quality assessment and analysis.
T275 907-919 Sentence denotes Participants
T276 920-1054 Sentence denotes Studies recruiting people presenting to primary care or outpatient hospital settings with suspicion of COVID‐19 disease were eligible.
T277 1055-1233 Sentence denotes For the initial version of this review, we included studies that recruited symptomatic people either known to have SARS‐CoV‐2 infection or known not to have SARS‐CoV‐2 infection.
T278 1234-1300 Sentence denotes Studies had to have a sample size of a minimum of 10 participants.
T279 1302-1313 Sentence denotes Index tests
T280 1314-1348 Sentence denotes All signs and symptoms, including:
T281 1349-1421 Sentence denotes signs such as oxygen saturation, measured by oximetry or blood pressure;
T282 1422-1463 Sentence denotes classic symptoms, such as fever or cough.
T283 1464-1646 Sentence denotes We included combinations of signs and symptoms, but not when they were combined with laboratory, imaging, or other types of index tests as these will be covered in the other reviews.
T284 1648-1665 Sentence denotes Target conditions
T285 1666-1721 Sentence denotes To be eligible studies had to identify at least one of:
T286 1722-1756 Sentence denotes mild or moderate COVID‐19 disease;
T287 1757-1776 Sentence denotes COVID‐19 pneumonia.
T288 1777-1947 Sentence denotes Asymptomatic infection with SARS‐CoV‐2 infection is out of scope for this review, considering it is by definition not possible to detect this based on signs and symptoms.
T289 1949-1968 Sentence denotes Reference standards
T290 1969-2038 Sentence denotes We anticipated that studies would use a range of reference standards.
T291 2039-2238 Sentence denotes Although RT‐PCR is considered the best available test, due to rapidly evolving knowledge about the target conditions, multiple reference standards on their own as well as in combination have emerged.
T292 2239-2281 Sentence denotes We expected to encounter cases defined by:
T293 2282-2295 Sentence denotes RT‐PCR alone;
T294 2296-2361 Sentence denotes RT‐PCR, clinical expertise, and imaging (for example, CT thorax);
T295 2362-2423 Sentence denotes repeated RT‐PCR several days apart or from different samples;
T296 2424-2518 Sentence denotes plaque reduction neutralisation test (PRNT) or enzyme‐linked immunosorbent assay(ELISA) tests;
T297 2519-2568 Sentence denotes information available at a subsequent time point;
T298 2569-2645 Sentence denotes World Health Organization (WHO) and other case definitions (see Appendix 1).
T299 2646-2727 Sentence denotes This list is not exhaustive, and we recorded all reference standards encountered.
T300 2728-2919 Sentence denotes With a group of methodological and clinical experts, we are producing a ranking of reference standards according to their ability to correctly classify participants using a consensus process.
T301 2920-3033 Sentence denotes We will use the ranking for informing the assessment of methodological quality in the next update of this review.