| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T27 |
0-7 |
Sentence |
denotes |
Fig. 1. |
| T28 |
9-43 |
Sentence |
denotes |
Structure and function of heparin. |
| T29 |
44-120 |
Sentence |
denotes |
Heparins are a heterogeneous mix of heparan sulfate (HS) glycosaminoglycans. |
| T30 |
121-263 |
Sentence |
denotes |
Each HS strand is composed of repeating disaccharide units of N-acetylglucosamine (GlcNAc) and glucuronic acid (GlcA) or iduronic acid (IdoA). |
| T31 |
264-353 |
Sentence |
denotes |
GlcNAc can be sulfated at three distinct sites (-6S, -NS, and -3S) and IdoA at one (-2S). |
| T32 |
354-528 |
Sentence |
denotes |
Unfractionated heparin is composed of HS chains that are >30 saccharides in length, whereas low-molecular weight heparin constituent HS chains are 22 saccharides or less (3). |
| T33 |
529-766 |
Sentence |
denotes |
The charge distribution of heparin imparted by the presence of the precise pentasaccharide sequence shown allows for the binding of heparin to serine protease inhibitor antithrombin-III (AT3), conferring its primary anticoagulant effect. |
| T34 |
767-932 |
Sentence |
denotes |
Innumerable other sulfation sequences are found in heparin preparations, which leads to binding and biologically relevant activity modulation of many other proteins. |
