| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T22 |
0-157 |
Sentence |
denotes |
Heparin is a heterogeneous preparation of long, linear highly sulfated heparan sulfate (HS) glycosaminoglycans purified from porcine intestines (see Fig. 1). |
| T23 |
158-312 |
Sentence |
denotes |
The sulfated nature of its constituent HS glycosaminoglycan chains confers heparin with the highest negative charge density of any known biomolecule (43). |
| T24 |
313-547 |
Sentence |
denotes |
This charge allows heparin to strongly and selectively interact with an immense number of proteins, the most classic being its interaction with serine protease inhibitor antithrombin-III (AT3) that provides its anticoagulant activity. |
| T25 |
548-714 |
Sentence |
denotes |
This anticoagulant activity is dependent on the presence of a precise pentasaccharide sequence within longer HS chains that allows for AT3 binding as shown in Fig. 1. |
| T26 |
715-969 |
Sentence |
denotes |
Beyond AT3, hundreds of biologically relevant, heparin-protein interactions have been described, which has led to the recognition of an immense number of potential off-target (both positive and negative) effects of heparin of unknown clinical importance. |
