PMC:7381711 / 16669-17432 JSONTXT 10 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T101 0-116 Sentence denotes The use of heparin as a therapeutic anticoagulant is associated with a 10–15% risk of significant bleeding (11, 27).
T102 117-335 Sentence denotes Factors that may increase bleeding risk are older age, worse illness severity, recent trauma or surgery, cardiopulmonary resuscitation, longer hospital stay, and decreased white blood cell and platelet counts (11, 27).
T103 336-420 Sentence denotes Many of these risk factors for bleeding are commonly seen in patients with COVID-19.
T104 421-558 Sentence denotes A second, albeit rare, complication of heparin therapy is HIT, which is estimated to occur in 0.2–3% of patients who receive heparin (4).
T105 559-763 Sentence denotes This feared adverse effect is driven by the development of antibodies specific to the protein platelet factor 4, which leads to life-threatening thrombocytopenia and paradoxical development of thrombosis.