| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T78 |
0-121 |
Sentence |
denotes |
Our developing understanding of the virology of SARS-CoV-2 suggests the biologic plausibility of heparin as an antiviral. |
| T79 |
122-268 |
Sentence |
denotes |
Theoretically, heparin may bind the SARS-CoV-2 spike protein and function as a competitive inhibitor for viral entry, thus decreasing infectivity. |
| T80 |
269-574 |
Sentence |
denotes |
Interestingly, shorter-length heparins, comparable to those found in therapeutic low-molecular weight heparin, did not appreciably bind the spike protein (17), suggesting that low-molecular weight formulations may be less likely to have direct antiviral activity through competitive spike protein binding. |
| T81 |
575-783 |
Sentence |
denotes |
If clinical trials demonstrate benefit of unfractionated heparin therapy, its effect could be partially due to this theoretical antiviral activity, rather than solely due to its anticoagulant properties (38). |
| T82 |
784-947 |
Sentence |
denotes |
As such, clinical trials with heparin should evaluate disease course and time to clearance of infection, as these outcomes would support direct antiviral activity. |
